Gallagher-Duval, Shawn published the artcileFunctionalized Polyhydroquinolines from Amino Acids Using a Key One-Pot Cyclization Cascade and Application to the Synthesis of (±)-Δ7-Mesembrenone, HPLC of Formula: 251320-63-5, the publication is Organic Letters (2021), 23(21), 8606-8611, database is CAplus and MEDLINE.
Substituted polyhydroquinolines are ubiquitous skeletal cores found in drugs and bioactive natural products. As a new route to access this motif, we successfully developed a one-pot cyclization cascade with high chemocontrol and diastereoselectivity. The sequence generates two cycles, three carbon-carbon bonds, and an all-carbon quaternary center in a highly convergent process. Functionalized polyhydroquinolines and congeners can be accessed from com. available amino acids. This versatile and robust strategy was applied to the synthesis of (±)-Δ7-mesembrenone.
Organic Letters published new progress about 251320-63-5. 251320-63-5 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (S)-tert-Butyl (1-hydroxy-3-methylbutan-2-yl)(methyl)carbamate, and the molecular formula is C11H23NO3, HPLC of Formula: 251320-63-5.
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