Convenient, functional group-tolerant, transition metal-free synthesis of aryl and heteroaryl trifluoromethyl ketones with the use of methyl trifluoroacetate was written by Funabiki, Kazumasa;Hayakawa, Ayaka;Inuzuka, Toshiyasu. And the article was included in Organic & Biomolecular Chemistry in 2018.Quality Control of Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate The following contents are mentioned in the article:
A new convenient, functional group-tolerant, transition metal-free route to aryl/heteroaryl trifluoromethyl ketones such as 4-EtO2CC6H4COCF3 under mild conditions was described. The reaction of not only aryl Grignard reagents carrying reducible electrophilic functional groups, such as ester and cyano groups, but also electron-deficient nitrogen-containing heteroaryl Grignard reagents with Me trifluoroacetate gave the corresponding aryl or heteroaryl trifluoromethyl ketones in good yields. Biol. assays revealed that new heteroaryl trifluoromethyl ketones carrying 2,4-dimethoxypyrimidine and 3,5-dimethylisoxazole rings showed good antitumor activities. This study involved multiple reactions and reactants, such as Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9Quality Control of Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate).
Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Quality Control of Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics