Synthesis of 4-unsubstituted dihydropyrimidines: Nucleophilic substitution at position-2 of dihydropyrimidines was written by Cho, Hidetsura;Nishimura, Yoshio;Yasui, Yoshizumi;Kobayashi, Satoshi;Yoshida, Shin-Ichiro;Kwon, Eun-Sang;Yamaguchi, Masahiko. And the article was included in Tetrahedron in 2011.Application In Synthesis of Ethyl 3-ethoxypropanoate The following contents are mentioned in the article:
Synthesis of novel 4-unsubstituted dihydropyrimidines (DPs) was performed. Subsequently, a variety of 4-unsubstituted 1,4(3,4)-DPs with amino moieties at position-2 were obtained in excellent yields by activation of position-2 owing to regioselective alkoxycarbonylation at position-3 of the DP skeleton. 3-Oxo-2-phenyl-2,3,5,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrimidine was obtained using phenylhydrazine instead of amines. Individual tautomers of 1,4(3,4)-DP were observed in the 1H NMR spectra of one derivative depending on temperature and concentration On the other hand, only 1,4-DP was found in the solid state by single-crystal X-ray crystallog. This study involved multiple reactions and reactants, such as Ethyl 3-ethoxypropanoate (cas: 763-69-9Application In Synthesis of Ethyl 3-ethoxypropanoate).
Ethyl 3-ethoxypropanoate (cas: 763-69-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application In Synthesis of Ethyl 3-ethoxypropanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics