Manganese-mediated reductive amidation of esters with nitroarenes was written by Cheung, Chi Wai;Shen, Ni;Wang, Shao-Peng;Ullah, Asim;Hu, Xile;Ma, Jun-An. And the article was included in Organic Chemistry Frontiers in 2019.Computed Properties of C13H18O3 The following contents are mentioned in the article:
A convenient and efficient method to synthesize N-aryl amides RNHC(O)R1 (R = 4-methylphenyl, 2H-1,3-benzodioxol-5-yl, quinolin-6-yl, etc; R1 = n-C6H13, cyclohexyl, 4-chlorophenyl, pyridin-3-yl, etc.) via amidation of esters R1C(O)OR2 (R2 = Et, benzyl, 2H-1,3-benzodioxol-5-ylmethyl, etc.) with nitroarenes RNO2 was reported. In the presence of manganese metal, this amidation proceeded smoothly without the need for addnl. catalysts or ligands. Various esters and nitroarenes are suitable substrates to afford a wide range of N-aryl amides, including bio-active mols. RNHC(O)R1 (R = 2-phenyl-1,3-benzoxazol-5-yl, R1 = Ph; R = 2-phenyl-1,3-benzoxazol-5-yl, R1 = benzyl) and intermediates I (X = H, Cl) to drug mols. e.g., II. This study involved multiple reactions and reactants, such as Methyl 2-(4-(tert-butyl)phenoxy)acetate (cas: 88530-52-3Computed Properties of C13H18O3).
Methyl 2-(4-(tert-butyl)phenoxy)acetate (cas: 88530-52-3) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C13H18O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics