Bioorthogonal Click and Release Reaction of Iminosydnones with Cycloalkynes was written by Bernard, Sabrina;Audisio, Davide;Riomet, Margaux;Bregant, Sarah;Sallustrau, Antoine;Plougastel, Lucie;Decuypere, Elodie;Gabillet, Sandra;Kumar, Ramar Arun;Elyian, Jijy;Trinh, Minh Nguyet;Koniev, Oleksandr;Wagner, Alain;Kolodych, Sergii;Taran, Frederic. And the article was included in Angewandte Chemie, International Edition in 2017.Product Details of 2253-73-8 The following contents are mentioned in the article:
We report the discovery of a new bioorthogonal click-and-release reaction involving iminosydnones and strained alkynes (e.g., I + II â?III + N-benzylurea). This transformation leads to two products resulting from the ligation and fragmentation of iminosydnones under physiol. conditions. Optimized iminosydnones were successfully used to design innovative cleavable linkers for protein modification, thus opening up new areas in the fields of drug release and target-fishing applications. This click-and-release technol. offers the possibility of exchanging tags on proteins for functionalized cyclooctynes under mild and bioorthogonal conditions. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Product Details of 2253-73-8).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Product Details of 2253-73-8
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics