Zhong, Qiqing published the artcileDevelopment of dinitrophenylated cyclodextrin derivatives for enhanced enantiomeric separations by high-performance liquid chromatography, Formula: C22H12F6O6S2, the publication is Journal of Chromatography A (2006), 1115(1-2), 19-45, database is CAplus and MEDLINE.
The synthesis and evaluation of new dinitrophenyl (DNP) substituted β-cyclodextrin (β-CD) chiral stationary phases (CSPs) for the enantioseparation of various classes of chiral analytes by HPLC are presented. The dinitrophenyl substituted β-CD derivatives were synthesized and covalently bonded to functionalized 5 μm spherical porous silica gel. These are the 1st reported derivatized cyclodextrin which contains π-electron deficient substituents (i.e., π-acidic moieties). The column performance in terms of their ability to sep. enantiomers is evaluated. A variety of different dinitro-substituted aryl groups were studied and compared. The pH of the mobile phase buffers, the buffer composition, the number and position of the dinitro groups on the Ph ring substituent, the degree of substitution, and the bonding strategy all greatly affect the performance of the CSPs. A large variety of racemic compounds were separated successfully on these CSPs. The bonded dinitrophenyl-derivatized cyclodextrins are stable in all three mobile phase modes, namely, the reversed-phase, polar organic, and normal phase modes. No degradation in column performance was observed in any mode of operation even after >1000 injections. The anal. applicability of these types of CSPs for enantiomeric separations is discussed.
Journal of Chromatography A published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C3H3Br2ClO, Formula: C22H12F6O6S2.
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