Xu, Zhidong published the artcileRadiosynthesis of a carbon-11 labeled PDE5 inhibitor [11C]TPN171 as a new potential PET heart imaging agent, Recommanded Product: Methyl 3-oxovalerate, the publication is Applied Radiation and Isotopes (2020), 109190, database is CAplus and MEDLINE.
To develop PET tracers for imaging of heart disease, a new carbon-11 labeled potent and selective PDE5 inhibitor [11C]TPN171 ([11C]9) has been synthesized. The reference standard TPN171 (9) and its corresponding precursor desmethyl-TPN171 (11) were synthesized from Me 3-oxovalerate and 2-hydroxybenzonitrile in 9 and 10 steps with 31% and 25% overall chem. yield, resp. The radiotracer [11C]TPN171 was prepared from desmethyl-TPN171 with [11C]CH3OTf through N-11C-methylation and isolated by HPLC purification followed by SPE formulation in 45-55% radiochem. yield, based on [11C]CO2 and decay corrected to EOB. The radiochem. purity was >99%, and the molar activity (Am) at EOB was in a range of 370-740 GBq/μmol.
Applied Radiation and Isotopes published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C22H18O2, Recommanded Product: Methyl 3-oxovalerate.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics