Umemoto, Nao published the artcileDevelopment of regioselective [2 + 3] cycloaddition reactions of nitrile oxides with alkenes using intramolecular reactions through oxime groups [1], Recommanded Product: Dimethyl fumarate, the publication is Tetrahedron (2022), 132833, database is CAplus.
Nitrile oxides afford 2-isoxazoline heterocycles through [2 + 3] cycloaddition reactions with alkenes. These heterocycles can be converted to useful intermediates, such as β-hydroxy ketones and γ-amino alcs., leading to pharmaceutical and agrochem. compounds However, nitrile oxides directly connected to a carbonyl group show low reactivity owing to the decrease in energy of the dipole HOMO. Furthermore, when dissym. internal alkenes are used, regioselective control is difficult. Herein, authors have designed nitrile oxides bound to alkenes through the oxime group and demonstrated their intramol. [2 + 3] cycloaddition reactions. The desired cycloadducts were obtained in high yields and as single regioisomers. Furthermore, face-selective cycloaddition reactions were achieved by introducing a stereocenter into the linker moiety, affording the desired cycloadducts with good diastereoselectivity.
Tetrahedron published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C12H23N3S, Recommanded Product: Dimethyl fumarate.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics