Oh, Tae Seok published the artcileItaconate and its derivatives repress early myogenesis in vitro and in vivo, Related Products of esters-buliding-blocks, the publication is Frontiers in Immunology (2022), 748375, database is CAplus and MEDLINE.
A Krebs cycle intermediate metabolite, itaconate, has gained attention as a potential antimicrobial and autoimmune disease treatment due to its anti-inflammatory effects. While itaconate and its derivatives pose an attractive therapeutic option for the treatment of inflammatory diseases, the effects outside the immune system still remain limited, particularly in the muscle. Therefore, we endeavored to determine if itaconate signaling impacts muscle differentiation. Utilizing the well-established C2C12 model of in vitro myogenesis, we evaluated the effects of itaconate and its derivatives on transcriptional and protein markers of muscle differentiation as well as mitochondrial function. We found itaconate and the derivatives di-Me itaconate and 4-octyl itaconate disrupt differentiation media-induced myogenesis. A primary biol. effect of itaconate is a succinate dehydrogenase (SDH) inhibitor. We find the SDH inhibitors di-Me malonate and harzianopyridone phenocopie the anti-myogenic effects of itaconate. Furthermore, we find treatment with exogenous succinate results in blunted myogenesis. Together our data indicate itaconate and its derivatives interfere with in vitro myogenesis, potentially through inhibition of SDH and subsequent succinate accumulation. We also show 4-octyl itaconate suppresses injury-induced MYOG expression in vivo. More importantly, our findings suggest the therapeutic potential of itaconate, and its derivatives could be limited due to deleterious effects on myogenesis.
Frontiers in Immunology published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Related Products of esters-buliding-blocks.
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https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics