Month: November 2022

Zhang, Zhicheng published the artcileGeneral chemoenzymatic route to two-stereocenter triketides employing assembly line ketoreductases, Quality Control of 30414-53-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(1), 157-160, database is CAplus and MEDLINE.

Modular polyketide synthases (PKSs) are enzymic assembly lines that fuse carbon fragments into complex chiral products. Here, their synthetic logic is employed to chemoenzymically generate two-stereocenter triketides. Each of the four stereoisomers was constructed in a stereocontrolled manner using C-acylation and two PKS ketoreductases possessing opposite stereoselectivities.

Chemical Communications (Cambridge, United Kingdom) published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C8H11BO2, Quality Control of 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yildirim, Muhammet published the artcileA rapid access to novel and diverse 3-oxothiazolo[3,2-c]pyrimidine-8-carboxylates using multicomponent Mannich cyclisation reactions, Product Details of C5H10O2S, the publication is Molecular Diversity (2015), 19(1), 1-13, database is CAplus and MEDLINE.

An efficient synthesis of 3-oxotetrahydrothiazolo[3,2-c]pyrimidine-8-carboxylate derivatives, e.g., I, was developed by double Mannich cyclization of 4-oxothiazolidines with formaldehyde and amines under very mild conditions. The benefits of this method involve simple and rapid one-pot multicomponent synthesis from com. available precursors, easy work-up, and excellent yields.

Molecular Diversity published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C19H14O2, Product Details of C5H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gercek, Yusuf Can published the artcileScreening of Plant Pollen Sources, Polyphenolic Compounds, Fatty Acids and Antioxidant/Antimicrobial Activity from Bee Pollen, SDS of cas: 121-79-9, the publication is Molecules (2022), 27(1), 117, database is CAplus and MEDLINE.

In this study, the botanical origin, total flavonoid and phenolic content, antioxidant activity, phenolic profile and fatty acid composition of mixed bee pollen loads collected in Bayburt, Turkey, were determined In addition to these assays, antibacterial activity of bee-collected pollen extract (BCPE) against a variety of food-borne pathogenic bacteria was determined in vitro. Pollen loads were classified into five botanical families based on their color: Asteraceae, Fabaceae, Campanulaceae, Cistaceae and Rosaceae. Total flavonoid, total phenolic, CUPRAC and CERAC concentrations were 173.52 mg GAE/g, 79.21 mg QE/g, 85.59 mg Trolox/g and 118.13 mg Trolox/g, resp. Twenty-three phenolic compounds were scanned in bee pollen extract by LC-MS/MS, with rutin being the most abundant. Cis-4,7,10,13,16,19 docosahexaenoic acid was the predominant fatty acid, followed by cis-11-eicosenoic acid, palmitic acid, and alfa linolenic acid. In addition, the agar well diffusion (AWD) and micro-broth dilution methods were used to determine of the antibacterial activity of the BCPE sample. MIC values were observed to vary between 2.5-5 mg/mL for Gram-pos. bacteria and 5-10 mg/mL for Gram-neg. bacteria. These findings indicate that bee pollen could be a potential source of antioxidants and antimicrobials.

Molecules published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, SDS of cas: 121-79-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Armada, Daniel published the artcileMiniaturized active air sampling method for the analysis of tire rubber pollutants from indoor and outdoor places, Application In Synthesis of 627-93-0, the publication is Journal of Separation Science (2021), 44(8), 1694-1705, database is CAplus and MEDLINE.

An effective, quick, and sustainable air anal. method was developed to analyze 41 volatiles and semivolatile organic compounds present in tire rubber and crumb rubber materials. The proposed method, based on active sampling using a sorbent material followed by an ultrasound assisted extraction, was developed with the aim of obtaining a fast and simple procedure to determine polycyclic aromatic hydrocarbons, plasticizers, antioxidants, and vulcanization agents in air. A small amount of sorbent (25 mg) was used, and the analytes were recovered in only 1 mL of solvent. An exptl. design was applied to study the influence of main factors such as type of sorbent and type of solvent, extraction technique (ultrasound-assisted extraction and vortex extraction), extraction time, as well as the factor interactions. Under optimal conditions, no breakthrough occurs in the studied interval (up to 4 m³). Linearity was demonstrated in a wide concentration range. Accuracy of the total sampling-extraction anal. was evaluated obtaining satisfactory recoveries as well as good precision. The method was successfully applied to different outdoor and indoor air environments, including a recycled rubber synthetic turf football pitch.

Journal of Separation Science published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, Application In Synthesis of 627-93-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sabatini, Stefano published the artcile8-Methyl-7-substituted-1,6-naphthyridine-3-carboxylic acids as new 6-desfluoroquinolone antibacterials, Recommanded Product: Ethyl 3-(dimethylamino)acrylate, the publication is Journal of Heterocyclic Chemistry (1999), 36(4), 953-957, database is CAplus.

1,6-Naphthyridine-8-methyl-7-substituted-3-carboxylic acids I (R = N-methylpiperazine, piperidine, 1,2,3,4-tetrahydroisoquinoline) were synthesized as new 6-desfluoroquinolone antibacterials in which the usual fluorine atom at C-6 position was replaced by an endocyclic nitrogen atom. The antibacterial activity of I proved less when compared to our previous 6-amino and 6-hydrogen counterparts. However, the presence of Me group at C-8 position provided good Gram-pos. antibacterial activity, with min. inhibitory concentration values on the same order of ciprofloxacin for the piperidinyl and tetrahydroisoquinolinyl derivatives

Journal of Heterocyclic Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Recommanded Product: Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bayardon, Jerome published the artcileChiral fluorous phosphorus ligands based on the binaphthyl skeleton: synthesis and applications in asymmetric catalysis, Application In Synthesis of 126613-06-7, the publication is Tetrahedron: Asymmetry (2003), 14(15), 2215-2224, database is CAplus.

Two enantiopure fluorous phosphines have been conveniently synthesized by combining palladium-catalyzed coupling reactions of easily available binaphthyl building blocks with the introduction of fluorous ponytails onto aromatic compounds via ether bond formation. These new fluorous chiral phosphines have been tested as ligands in metal-catalyzed asym. transformations, the best results being obtained in the palladium-catalyzed asym. allylic substitution of 1,3-diphenyl-2-propenyl acetate, affording products with up to 87% e.e.

Tetrahedron: Asymmetry published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C22H12F6O6S2, Application In Synthesis of 126613-06-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

de Jesus, Jany H. F. published the artcileTHERMOANALYTICAL STUDIES ON NEW POLYMORPHIC FORMS OF PROPYL, OCTYL AND DODECYL GALLATES, HPLC of Formula: 121-79-9, the publication is Thermochimica Acta (2022), 179114, database is CAplus.

The thermal behavior of Pr (PG), octyl (OG) and dodecyl (DG) gallates, three antioxidants widely used in fuel and food industries, was evaluated by thermoanal. techniques (TG, DTA, DSC and hot stage microscopy), and complementary techniques, such as FTIR-ATR and XRD. All of them presented melting in characteristic temperatures during heating. The resulting liquid phases crystallized in different solid forms when cooled just after melting. However, when the samples were heated beyond melting temperature, they decomposed Although thermal studies were conducted at higher temperature than those in which they are regularly used, this work provided relevant information regarding their thermal behavior at higher temperatures Data from XRD, FTIR-ATR and hot stage microscopy were used to confirm the presence of new polymorphs. Finally, based on these results mechanisms describing the thermal behavior of PG, OG and DG were proposed.

Thermochimica Acta published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, HPLC of Formula: 121-79-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Barlaam, Bernard published the artcileDiscovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies, Name: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine, the publication is Journal of Medicinal Chemistry (2020), 63(24), 15564-15590, database is CAplus and MEDLINE.

A CDK9 inhibitor having short target engagement would enable a reduction of Mcl-1 activity, resulting in apoptosis in cancer cells dependent on Mcl-1 for survival. We report the optimization of a series of amidopyridines (from compound 2), focusing on properties suitable for achieving short target engagement after i.v. administration. By increasing potency and human metabolic clearance, we identified compound 24, a potent and selective CDK9 inhibitor with suitable predicted human pharmacokinetic properties to deliver transient inhibition of CDK9. Furthermore, the solubility of 24 was considered adequate to allow i.v. formulation at the anticipated ED. Short-term treatment with compound 24 led to a rapid dose- and time-dependent decrease of pSer2-RNAP2 and Mcl-1, resulting in cell apoptosis in multiple hematol. cancer cell lines. Intermittent dosing of compound 24 demonstrated efficacy in xenograft models derived from multiple hematol. tumors. Compound 24 is currently in clin. trials for the treatment of hematol. malignancies.

Journal of Medicinal Chemistry published new progress about 1383675-83-9. 1383675-83-9 belongs to esters-buliding-blocks, auxiliary class Boronic acid and ester,Boronic acid and ester, name is 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine, and the molecular formula is C12H19BN2O3, Name: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Godoy, William M. published the artcileKinetic modeling of glycerol acetylation catalyzed by styrene-divinylbenzene and styrene-trimethylolpropane triacrylate sulfonated resins, Recommanded Product: Trimethylolpropane triacrylate, the publication is Reaction Kinetics, Mechanisms and Catalysis (2022), 135(1), 233-245, database is CAplus.

The present work reports a kinetic comparison between two resins made with different cross-linkers, Amberlyst 36 and PS-TMPTA. The latter was synthesized in this study. Both resins were used as catalysts in glycerol acetylation in a batch reactor at 80 and 90°C, with 5 and 10 g L^-1 of catalyst concentration under a molar ratio 4:1 of acetic acid/glycerol. The synthesized resin (PS-TMPTA) presented low ion exchange capacity (1.5 mmol g^-1) compared to the com. resin (Amberlyst 36, 5.45 mmol g^-1), but both presented similar efficiency in catalysis, probably due to the difference in crosslinking densities. The exptl. results explain the resins behavior and properties in detail (ion exchange capacities, swelling index and catalytic efficiency) and the kinetic models were compared utilizing the difference between the corrected Akaike Information Criterion (ΔAICc), Standard Deviation (s) and P-value (student t distribution). According to the results, the irreversible first order model had the best fit of the two models for the exptl. conditions studied for this work.

Reaction Kinetics, Mechanisms and Catalysis published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Recommanded Product: Trimethylolpropane triacrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Willcox, Darren published the artcileAsymmetric ketone hydroboration catalyzed by alkali metal complexes derived from BINOL ligands, Name: (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), the publication is Dalton Transactions (2020), 49(8), 2417-2420, database is CAplus and MEDLINE.

The ability of alkali metal complexes featuring functionalized BINOL-derived ligands to catalyze ketone hydroboration reactions was explored. The reduced products were formed in excellent yields and with variable enantioselectivities dependent upon the nature of the ligand and the alkali metal cation.

Dalton Transactions published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C7H6O3, Name: (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate).

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics