Month: November 2022

Chen, Zhen published the artcileA design principle of polymers processable into 2D homeotropic order, Name: Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, the publication is Nature Communications (2016), 13640, database is CAplus and MEDLINE.

How to orient polymers homeotropically in thin films has been a long-standing issue in polymer science because polymers intrinsically prefer to lie down. Here we provide a design principle for polymers that are processable into a 2D homeotropic order. The key to this achievement was a recognition that cylindrical polymers can be designed to possess oppositely directed local dipoles in their cross-section, which possibly force polymers to tightly connect bilaterally, affording a 2D rectangular assembly. With a phys. assistance of the surface grooves on Teflon sheets that sandwich polymer samples, homeotropic ordering is likely nucleated and gradually propagates upon hot-pressing towards the interior of the film. Consequently, the 2D rectangular lattice is constructed such that its b axis (side chains) aligns along the surface grooves, while its c axis (polymer backbone) aligns homeotropically on a Teflon sheet. This finding paves the way to molecularly engineered 2D polymers with anomalous functions.

Nature Communications published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Name: Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ugarenko, Michal published the artcileDevelopment of Pluronic micelle-encapsulated doxorubicin and formaldehyde-releasing prodrugs for localized anticancer chemotherapy, Product Details of C10H18O4, the publication is Oncology Research (2009), 17(7), 283-299, database is CAplus and MEDLINE.

The chemotherapeutic agent doxorubicin forms drug-DNA adducts that are enhanced by formaldehyde-releasing prodrugs such as AN-9. One of the major limitations of doxorubicin is dose-limiting cardiotoxicity; therefore, the use of a targeting strategy that enables drug delivery and release at tumor sites is of great interest. The major aim of this study was to use the Pluronic-ultrasound delivery system to encapsulate doxorubicin and formaldehyde-releasing prodrugs within Pluronic micelles, and then use ultrasound to trigger controlled drug release from micelles. Pluronic micelles themselves were not stable upon dilution and required the use of a stabilizing agent DSPE-PEG2000 to form stable “mixed micelles.”. Following the separation of free doxorubicin, approx. 60% of doxorubicin remained encapsulated within mixed micelles with a retention half-life of approx. 12 h. The formaldehyde-releasing prodrugs, however, were not retained within mixed micelles, but could potentially be administered sep. to doxorubicin-loaded micelles to achieve tumor-localized formation of doxorubicin-DNA adducts. The use of low-frequency, high-power ultrasound (20 kHz, 100 W/cm²) released 7-10% of doxorubicin from mixed micelles. Collectively, these results indicate that the Pluronic-ultrasound system could be used to deliver and release doxorubicin with the potential of forming cytotoxic DNA adducts at tumor sites with coadministrated formaldehyde-releasing prodrugs.

Oncology Research published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C12H10FeO4, Product Details of C10H18O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chansang, Arpaporn published the artcileSynergy in the adulticidal efficacy of essential oils for the improvement of permethrin toxicity against Aedes aegypti L. (Diptera: Culicidae), COA of Formula: C14H26O2, the publication is Parasites & Vectors (2018), 417/1-417/16, database is CAplus and MEDLINE.

In a previous screening program for mosquitocides from local edible plants in Thailand, essential oils (EOs) of Cyperus rotundus, Alpinia galanga and Cinnamomum verum, were found to possess promising adulticidal activity against Aedes aegypti. With the aim of reducing usage of conventional insecticides and improving the management of resistant mosquito populations, this study was designed to determine the potential synergism in the adulticidal efficacy of EOs on permethrin toxicity against Ae. aegypti, both pyrethroid-resistant and -susceptible strains. EOs extracted from rhizomes of C. rotundus and A. galanga as well as C. verum barks were evaluated for chem. compositions and adulticidal activity against Muang Chiang Mai-susceptible (MCM-S) and Pang Mai Dangresistant (PMD-R) strains of Ae. aegypti. Adulticidal bioassays of EO-permethrin mixtures for synergistic activity were also performed on these Ae. aegypti strains. Chem. characterization by the GC-MS anal. technique demonstrated that 48 compounds were identified from the EOs of C. rotundus, A. galanga and C. verum, representing 80.22%, 86.75% and 97.24%, resp., of all compositions Cyperene (14.04%), β-bisabolene (18.27%) and cinnamaldehyde (64.66%) were the main constituents of C. rotundus, A. galanga and C. verum oils, resp. In adulticidal bioassays, EOs of C. rotundus, A. galanga and C. verum were effective in killing Ae. aegypti, both MCM-S and PMD-R strains, with LD₅₀ values of 10.05 and 9.57μg/mg female, 7.97 and 7.94μg/mg female, and 3.30 and 3.22μg/mg female, resp. The adulticidal efficacy against MCM-S and PMD-R Ae. aegypti of these EOs was close to that of piperonyl butoxide (PBO, LD₅₀ values = 6.30 and 4.79μg/mg female, resp.) but less pronounced than that of permethrin (LD₅₀ values = 0.44 and 3.70 ng/mg female, resp.). Nevertheless, combination-based bioassays discovered the accomplished synergism of EOs together with permethrin. Significant synergistic effects with permethrin against both the strains of Ae. aegypti were recorded in the EOs of C. rotundus and A. galanga. Addition of C. rotundus and A. galanga oils decreased the LD₅₀ values of permethrin against MCM-S dramatically from 0.44 to 0.07 and 0.11 ng/ mg female, resp., with synergism ratio (SR) values of 6.28 and 4.00, resp. Furthermore, EOs of C. rotundus and A. galanga also reduced the LD₅₀ values of permethrin against PMD-R drastically from 3.70 to 0.42 and 0.003 ng/mg female, resp., with SR values of 8.81 and 1233.33, resp. The synergy of enhanced adulticidal toxicity recorded from EO-permethrin combinations against both strains of Ae. aegypti presents a promising role of EOs as a synergist for improving mosquitocidal efficacy, particularly in situations where conventional compounds are ineffective or inappropriate.

Parasites & Vectors published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, COA of Formula: C14H26O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tappan, Erin published the artcileActivation of Protein Phosphatase 1 by a Small Molecule Designed to Bind to the Enzyme’s Regulatory Site, Computed Properties of 106391-88-2, the publication is Chemistry & Biology (Cambridge, MA, United States) (2008), 15(2), 167-174, database is CAplus and MEDLINE.

The activity of protein phosphatase 1 (PP1), a serine-threonine phosphatase that participates ubiquitously in cellular signaling, is controlled by a wide variety of regulatory proteins that interact with PP1 at an allosteric regulatory site that recognizes a “loose” consensus sequence (usually designated as RVXF) found in all such regulatory proteins. Peptides containing the regulatory consensus sequence have been found to recapitulate the binding and PP1 activity modulation of the regulatory proteins, suggesting that it might be possible to design small-mol. surrogates that activate PP1 rather than inhibiting it. This prospect constitutes a largely unexplored way of controlling signaling pathways that could be functionally complementary to the much more extensively explored stratagem of kinase inhibition. Based on these principles, we have designed a microcystin analog that activates PP1.

Chemistry & Biology (Cambridge, MA, United States) published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C10H11NO4, Computed Properties of 106391-88-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Reddy Guduru, Shiva Krishna published the artcileSynthesis of Enantiomerically Pure 3-Substituted Piperazine-2-acetic Acid Esters as Intermediates for Library Production, Application In Synthesis of 106391-88-2, the publication is Journal of Organic Chemistry (2018), 83(19), 11777-11793, database is CAplus and MEDLINE.

Differentially protected 2,3-disubstituted piperazineacetates such as I and II (R = Me, PhCH₂, i-Bu; Ns = 2-O₂NC₆H₄SO₂; Boc = t-BuO₂C) were prepared for potential use in the synthesis of piperidine-containing combinatorial libraries. The piperazineacetates were prepared from L- or D-amino acids by acid reduction, oxidation and stereoselective Wittig olefination, Michael addition, amine protection with NsCl, cyclocondensation, and Boc deprotection and reprotection; the diastereomeric piperazines were separated Twenty monoprotected chiral 2,3-disubstituted piperazines, were prepared as single absolute stereoisomers; all but one were prepared in multigram quantities.

Journal of Organic Chemistry published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C10H19NO3, Application In Synthesis of 106391-88-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Khutorianskyi, Andrii published the artcileDifluoromethyl Nitrile Oxide (CF₂HCNO): A Neglected Chemical Reagent, Formula: C7H13NO2, the publication is European Journal of Organic Chemistry (2017), 2017(27), 3935-3940, database is CAplus.

The synthesis of CF₂H-isoxazoles I [R = CN, C(O)CH₃, CO₂Me, etc.] via [3+2]-cycloaddition of a novel chem. reagent – difluoromethyl nitrile oxide (CF₂HCNO) in-situ generated from difluoromethylacetaldehyde oximes with alkynes/enamines was reported. These products were promising cores for agrochem. A representative CHF₂-isoxazole was incorporated into the known fungicide Fluxapyroxad and the synthesized analog showed higher antifungal activity than the parent fungicide.

European Journal of Organic Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Formula: C7H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Moritz, Jan-Ole published the artcileP-Chirogenic Diphosphazanes with Axially Chiral Substituents and Their Use in Rh-Catalyzed Asymmetric Hydrogenation, Synthetic Route of 617-52-7, the publication is Journal of Organic Chemistry (2020), 85(22), 14537-14544, database is CAplus and MEDLINE.

A convenient synthesis of enantiopure P-chirogenic diphosphazanes incorporating bulky bisphenol and 1,1′-bi-2-naphthol-derived substituents via the functionalization of a readily accessible enantiopure lithium phosphinoamide with chlorophosphoridites was developed. Since the product requires no subsequent deprotection, the protocol provides an easy, convenient synthesis of P-chirogenic ligands on the gram scale. The ligands were applied in the Rh-catalyzed asym. hydrogenation of benchmark substrates furnishing enantiomeric excess values up to 96%.

Journal of Organic Chemistry published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Synthetic Route of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Stenzel, Katharina published the artcileIsophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni, Application In Synthesis of 1877-71-0, the publication is Archiv der Pharmazie (Weinheim, Germany) (2017), 350(8), n/a, database is CAplus and MEDLINE.

Schistosoma mansoni histone deacetylase 8 (SmHDAC8) has been recently identified as a new potential target for the treatment of schistosomiasis. A series of newly designed and synthesized alkoxyamide-based and hydrazide-based HDAC inhibitors were tested for inhibitory activity against SmHDAC8 and human HDACs 1, 6, and 8. The front runner compounds showed submicromolar activity against SmHDAC8 and modest preference for SmHDAC8 over its human orthologue hHDAC8. Docking studies provided insights into the putative binding mode in SmHDAC8 and allowed rationalization of the observed selectivity profile.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C11H8O3, Application In Synthesis of 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Santana Andrade, Julianna Karla published the artcileBioaccessibility of bioactive compounds after in vitro gastrointestinal digestion and probiotics fermentation of Brazilian fruits residues with antioxidant and antidiabetic potential, Product Details of C10H12O5, the publication is LWT–Food Science and Technology (2022), 112469, database is CAplus.

The aim of this study was to analyze the aqueous and ethanolic extracts of fruits (pomegranate, jambolan, jackfruit, physalis and bitter melon) residues regarding the assessment of α-amylase inhibition, cytotoxicity and bioaccessibility of phenolic compounds, flavonoids and antioxidants after the in vitro gastrointestinal digestion and fermentation with probiotics and phenolic compounds by UFLC-DAD. The extracts showed a high rate of α-amylase inhibition, presenting a possible antidiabetic potential. The cytotoxicity test showed good response at the tested concentrations (10, 50, 100 and 1000 μg/mL). The contents of phenolics total after digestion and the fermentation, ranged from 483 ± 4 to 9816 ± 80 mg GAE/100g. ORAC method showed a significant increase in the antioxidant activity with bioaccessibility index above 100% for most extracts, ranging from 221 ± 9 to 868 ± 34%. The bioaccessibility of the catechin, protocatechuic acid, gallic, vanillic, Pr gallate and pyrocatecol compounds has been reported firsthand for some residues. Thus, bioactive compounds present in the fruit residues can be released during gastrointestinal digestion, being good sources of natural antioxidants and with promising potential benefits for human health.

LWT–Food Science and Technology published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Product Details of C10H12O5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Santana Andrade, Julianna Karla published the artcileInfluence of in vitro gastrointestinal digestion and probiotic fermentation on the bioaccessibility of gallic acid and on the antioxidant potential of Brazilian fruit residues, Synthetic Route of 121-79-9, the publication is LWT–Food Science and Technology (2022), 112436, database is CAplus.

This study aims to investigate the fruit residues of cashew apple and soursop regarding their chem. composition (sugars, carotenoids and organic acids by HPLC-DAD/RID), total phenolics, flavonoids, antioxidant capacities (ABTS, DPPH, FRAP and ORAC), inhibition of α-amylase enzyme, cytotoxicity by cell viability of fibroblast cells lines (L929). The aqueous and ethanolic extracts were submitted to simulated in vitro gastrointestinal digestion and probiotic fermentation (Lactobacillus delbrueckii, Lactobacillus jhonsoni, Lactobacillus rhamnosus and Bifidobacterium longum). The bioaccessibility of individual phenolic compounds was evaluated by UFLC-DAD system. The results revealed high bioaccessibility index for total phenolics (74.91 ± 1.10 to 475.25 ± 2.92%), flavonoids (27.86 ± 0.61 to 111.65 ± 0.94%), antioxidant capacity ORAC (131.40 ± 1.92 to 813.32 ± 21.13%). β-Carotene, citric acid, gallic acid, catechin, pyrocatechol, vanillin, quercetin, protocatechuic acid and Pr gallate were the most important compounds The extracts showed good inhibition of α-amylase, cell viability and high bioaccessibility of gallic acid compound (960.74 ± 0.00 to 1347.28 ± 51.75%). This study suggests that gastrointestinal digestion and probiotic fermentation of fruit residues increase the bioaccessibility of phenolic compounds with highly promising antioxidant potential for human health benefits.

LWT–Food Science and Technology published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Synthetic Route of 121-79-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics