Month: November 2022

Luo, Jie; Fishburn, James; Hahn, Steven; Ranish, Jeffrey published the artcile< An integrated chemical cross-linking and mass spectrometry approach to study protein complex architecture and function>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is protein interaction structure BDRG chem cross linking mass spectrometry.

Knowledge of protein structures and protein-protein interactions is essential for understanding biol. processes. Chem. crosslinking combined with mass spectrometry is an attractive approach for studying protein-protein interactions and protein structure, but to date its use has been limited largely by low yields of informative cross-links (because of inefficient crosslinking reactions) and by the difficulty of confidently identifying the sequences of cross-linked peptide pairs from their fragmentation spectra. Here we present an approach based on a new MS labile crosslinking reagent, BDRG (biotin-aspartate-Rink-glycine), which addresses these issues. BDRG incorporates a biotin handle (for enrichment of cross-linked peptides prior to MS anal.), two pentafluorophenyl ester groups that react with peptide amines, and a labile Rink-based bond between the pentafluorophenyl groups that allows cross-linked peptides to be separated during MS and confidently identified by database searching of their fragmentation spectra. We developed a protocol for the identification of BDRG cross-linked peptides derived from purified or partially purified protein complexes, including software to aid in the identification of different classes of cross-linker-modified peptides. Importantly, our approach permits the use of high accuracy precursor mass measurements to verify the database search results. We demonstrate the utility of the approach by applying it to purified yeast TFIIE, a heterodimeric transcription factor complex, and to a single-step affinity-purified preparation of the 12-subunit RNA polymerase II complex. The results show that the method is effective at identifying cross-linked peptides derived from purified and partially purified protein complexes and provides complementary information to that from other structural approaches. As such, it is an attractive approach to study the topol. of protein complexes.

Molecular and Cellular Proteomics published new progress about Cellular retinol-binding protein 3 Role: BSU (Biological Study, Unclassified), PEP (Physical, Engineering or Chemical Process), BIOL (Biological Study), PROC (Process). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sahu, Dhananjay; Sahu, Raj Kumar; Patra, Karali published the artcile< Effects of crosslink density on the behavior of VHB 4910 dielectric elastomer>, Quality Control of 3290-92-4, the main research area is acrylic elastomer trimethylolpropane trimethylacrylate crosslink density mech property.

Interpenetration of dielec. elastomers with fillers is an effective technique to improve requisite properties for voltage induced electromech. performance. However, the requirement that the rigid frame has to maintain its pre-strained state, and time/temperature related phenomenon like stress relaxation/concentration, strain-induced crystallization and void propagation etc., limits this technol. To overcome these limitations, thermochem. and UV irradiation techniques of polymerization are used to modify the macromol. structures of VHB 4910 elastomer with crosslink monomers. Both the methods are compared in terms of the modification in surface and mol. structure through optical microscope and IR spectroscopy, resp. Thermochem. modified samples are found flawless with regular surface reformation; crosslink d. is evaluated and its influences on hysteresis, dielec. constant and material degradation at elevated temperature are characterized. Results from this study may contribute towards the complete understanding of space d. for inclusion of filler, used for material development with user-defined properties.

Journal of Macromolecular Science, Part A: Pure and Applied Chemistry published new progress about Acrylic rubber Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation) (VHB 4910, reaction products with trimethylolpropane trimethylacrylate). 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Quality Control of 3290-92-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ebert, E.; Eckhardt, W.; Jaekel, K.; Moser, P.; Sozzi, D.; Vogel, C. published the artcile< Quantitative structure activity relationships of fungicidally active triazoles: analogs and stereoisomers of propiconazole and etaconazole>, Electric Literature of 112-63-0, the main research area is fungicide triazole derivative structure ergosterol; propiconazole stereoisomer fungicide sterol metabolism; ectaconazole stereoisomer fungicide sterol metabolism; QSAR triazole fungicide.

The preparation of the 4 stereoisomers of propiconazole (TILT) is described. Their inhibition of the 14α-C-demethylation of the sterol nucleus is examined and compared with the inhibition by the four stereoisomers of etaconazole (SONAX). The quant. structure-activity relationships (QSAR) of substituted 1,3-dioxolane-2-yl-methyltriazoles and 1,3-dioxane-2-yl-methyltriazoles on in vivo fungicidal activity are investigated.

Zeitschrift fuer Naturforschung, C: Journal of Biosciences published new progress about Agrochemical fungicides. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

French, Frederic A.; DoAmaral, Jefferson R.; Blanz, Erwin J. Jr.; French, Douglas A. published the artcile< Antimalarial activity of guanylhydrazone salts of aromatic ketones. 2. Development of active polyhalo derivatives>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is antimalarial halobenzophenone guanyl hydrazones; Plasmodium benzophenones guanylhydrazones.

The requirement for the antimalarial activity of the halogen-substituent benzophenone guanylhydrazones Ph2C:NNHC(NH2:HCl) was the presence of a CF3 group in the 3 or 4 position or a F3CO group in the 4 position on one ring, and a halogen or CF3 in the 3 or 4 position of the 2nd ring. Twenty-five compounds containing halogen, CF3 or F3CO groups, substituted in various ring positions were synthesized by known methods and tested on mice infected with Plasmodium berghei. Fifteen compounds were active and 16 were partially curative. Twelve compounds produced 100% cures at one or more dose levels. 3,4-Dichloro-4′-trifluoromethylbenzophenone guanylhydrazone-HCl (I-HCl) was outstanding and yielded 100% cures with 80-640 mg/kg doses. Replacement of H by Me in the guanidine moiety abolished the antimalarial activity.

Journal of Medicinal Chemistry published new progress about Malaria. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ma, Jun-An; Cahard, Dominique published the artcile< Screening of chiral catalysts for enantioselective electrophilic fluorination of β-keto esters. [Erratum to document cited in CA142:197594]>, COA of Formula: C19H34O2, the main research area is erratum stereoselective fluorination keto ester chiral ligand.

Line 36 should read: “”Sodeoka et al. described an efficient en antioselective fluorination of various acyclic and cyclic β-ketoesters catalysed by chiral BINAP-palladium complexes [9].””. The corrected version of Scheme 1 is also given.

Journal of Fluorine Chemistry published new progress about Chiral ligands Role: CAT (Catalyst Use), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Grob, C. A.; Weissbach, O. published the artcile< The preparation of oxindole derivatives from o-chloronitrobenzenes and cyanoacetic and malonic acid esters>, Category: esters-buliding-blocks, the main research area is .

Chlorobenzenes activated by a single o-NO2 group underwent smooth nucleophilic substitution by the K derivatives of NCCH2CO2Et (I) and CH2(CO2Et)2 (II) in Me3COH as solvent. The resulting 2-nitrophenylmalonic ester derivs, were readily converted into o-O2NC6H4CH2CO2H (III) and derivatives of oxindole and indole resp. I (49.0 g.) and then 31.5 g. o-O2NC6H4Cl (IV) in 75 cc. hot absolute Me3COH added with stirring to 16.3 g. K in 370 cc. absolute Me3COH, refluxed 10 hrs. with stirring, cooled, acidified with dilute HCl, and concentrated in vacuo at 30-40°, the residue dissolved in Et2O and extracted with dilute aqueous Na2CO3, and the aqueous extract acidified and extracted with Et2O gave 33.0 g. o-O2NC6H4CH(CN)CO2Et (V), prisms, m. 59-60° (MeOH and sublimed at 50°÷0.1 mm.) (all m.ps. are corrected), b0.09 139-41°; the forerun from the distillation of the V deposited 3-6% anthroxanic acid nitrile (VI), needles, m. 58-9° (Me2CO and sublimed at 50°÷11 mm.). VI refluxed 12 hrs. with 1:1 AcOH-20% HCl gave nearly 100% anthroxanic acid (VII), needles, m. 187-95° (decomposition) with the formation of a decomposition product, m. above 230°. VI heated with MeOH-HCl gave the Me ester of VII, needles, m. 67-8° (aqueous Me2CO). V (9.4 g.) in 80 cc. N Na2CO3 kept 10 days at 22° deposited 5.8 g. o-O2NC6H4CH2CN (VIII), leaflets, m. 82-4°. IV (10.5 g.) treated in the usual manner with I and the aqueous Na2CO3 phase from the processing kept 14 days at 25° gave 8.1 g. VIII, light yellow lancets, m. 82-3° (aqueous MeOH). V (5.0 g.) refluxed 15 hrs. with 50 cc. 2:1 AcOH-20% HCl and evaporated in vacuo, the residue partitioned between Et2O and H2O, the Et2O layer extracted with 2N KHCO3, and the extract acidified and extracted with Et2O yielded 3.4 g. III, light yellow needles, m. 139-41° (aqueous Me2CO). V (1 g.) in 15 cc. AcOH heated 45 min. with occasional shaking on the steam bath with 0.75 g. Fe powder and evaporated, the residue dissolved in Et2O, and the product isolated with 2N KHCO3 yielded 0.6 g. 2-amino-3-carbethoxyindole, leaflets, m. 180-1° (sublimed at 150°÷0.2 mm.) (C6H6-petr. ether). II (61.5 g.) and then 30 g. IV in 50 cc. Me3COH refluxed 26 hrs. with 15 g. K in 350 cc. absolute Me3COH under N, acidified with dilute H2SO4, concentrated in vacuo at about 40°, and extracted with Et2O, the residual crude o-O2NC6H4CH(CO2Et)2 (IX) distilled twice at 0.3 mm. yielded 19 g. Et ester of VII, needles, m. 66-7° (MeOH), and a smaller amount of Et ester of III, needles, m. 64-5° (MeOH). Crude IX from a similar run refluxed 15 hrs. with 125 cc. AcOH and 125 cc. 20% HCl and worked up in the usual manner gave 18 g. III. II (82 g.) and then 47 g. 2,3-Cl2C6H3NO2 in 40 cc. hot absolute Me3COH added to 19.9 g. K in 430 cc. Me3COH, refluxed 20 hrs. with stirring, and evaporated in vacuo, and the residue acidified with dilute HCl and extracted with Et2O gave 112 g. 2,6-Cl(O2N)C6H3CH(CO2Et)2 (X). The crude X refluxed 24 hrs. with 600 cc. AcOH and 400 cc. 20% HCl and evaporated in vacuo, the residue partitioned between Et2O and 2N KHCO3, and the aqueous phase acidified and extracted with Et2O yielded 44.3 g. 2,6-Cl(O2N)C6H3CH2CO2H, m. 190-2° (aqueous Me2CO).

Helvetica Chimica Acta published new progress about 30095-98-8. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tabata, Toshikazu; Shibazaki, Toshio published the artcile< Fluorescent photometer using a low pressure mercury arc>, Formula: C19H34O2, the main research area is .

The construction of a simplified fluorescent photometer, easy to make and suitable as a portable meter, is described. A low pressure Hg lamp, 4 w., is used as the source of exciting light. The filtered fluorescent light is detected by a photomultiplier combined with an amplifier operated by dry cells.

Bunseki Kagaku published new progress about Fluorescence spectrometers. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cortes-Clerget, Margery; Lee, Nicholas R.; Lipshutz, Bruce H. published the artcile< Synthetic chemistry in water: Applications to peptide synthesis and nitro group reductions>, Safety of H-Leu-OEt.HCl, the main research area is peptide synthesis coupling water green chem solvent cosolvent; amine synthesis nitro group reduction carbonyl iron powder safety.

Amide bond formation and aromatic/heteroaromatic nitro-group reductions represent two of the most commonly used transformations in organic synthesis. Unfortunately, such processes can be especially wasteful and hence environmentally harmful, and may present safety hazards as well, given the reaction conditions involved. The two protocols herein describe alternative technologies that offer solutions to these issues. Polypeptides can now be made in water at ambient temperatures using small amounts of the designer surfactant TPGS-750-M, thereby eliminating the use of organic solvents as the reaction medium. Likewise, a safe, inexpensive and efficient procedure is outlined for nitro-group reductions, using industrial iron in the form of carbonyl iron powder (CIP), an inexpensive item of commerce. The peptide synthesis will typically take, overall, 3-4 h for a simple coupling and 8 h for a two-step deprotection/coupling process. The workup usually consists of a simple extraction and acidic/basic aqueous washings. The nitro reduction procedure will typically take 6-8 h to complete, including setup, reaction time and workup.

Nature Protocols published new progress about Amide group (amide bond). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Safety of H-Leu-OEt.HCl.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gaballa, Heba; Theato, Patrick published the artcile< Glucose-Responsive Polymeric Micelles via Boronic Acid-Diol Complexation for Insulin Delivery at Neutral pH>, Electric Literature of 71195-85-2, the main research area is insulin micelle boronic acid polymer diabetes.

In the present study, glucose-responsive polymeric complex micelles based on the complexation of phenylboronic-acid-based (PBA-based) block copolymer and diol-functionalized polymers are reported. The phenylboronic-acid- and diol-based block copolymers were successfully synthesized in only two reaction steps using reversible addition-fragmentation chain-transfer (RAFT) polymerization and postpolymn. modification of the obtained poly[(N-acryloylmorpholine-block-(N-acryloylmorpholine-co-pentafluorophenyl acrylate)], poly[(AMP-b-(AMP-co-PFPA)], reactive block copolymer. The self-assembly of the complex micelles was investigated under neutral conditions using dynamic light scattering (DLS) and transmission electron microscopy (TEM). The interaction of the PBA block copolymer and diol-containing polymer via boronate ester bond was investigated by 1H NMR and UV-vis spectroscopy. The complex micelles enhanced the glucose responsiveness under physiol. conditions compared to simple PBA micelles. Furthermore, the successful glucose-triggered release of FITC-insulin from the polymeric micelles was investigated.

Biomacromolecules published new progress about Antidiabetic agents. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Electric Literature of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Baker, Sarah E.; Baker, Alexander A.; Orme, Christine A.; Worthington, Matthew A.; Li, Tian T.; Sedillo, Edwin M.; Dudoff, Jessica; Lee, Jonathan R. I.; Kuntz, Joshua D.; McCall, Scott K. published the artcile< Calcium vapor synthesis of extremely coercive SmCo5>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is samarium cobalt coercive calcium vapor synthesis.

Exceptionally coercive SmCo5 particles are produced through calcium vapor reduction of SmCo5O9 powders synthesized by flame spray pyrolysis. The resulting powders are composed of oblate hexagonal particles approx. 2 μ across with smooth surfaces. This microstructure yields record-breaking room temperature coercivity Hc,i >80 kOe, or >60 kOe when combined with advanced manufacturing approaches such as electrophoretic deposition or molding with tetraglyme inks. These techniques enable straightforward low-loss fabrication of bulk parts. The high coercivity is extremely robust at elevated temperatures, exceeding 10 kOe even at 600 °C. The oxide precursor approach removes the need for strict environmental control during synthesis that is common to other nanoparticle-based routes and can readily be scaled to kilogram quantities of feedstock production Magnet powders produced by calcium vapor reduction can thus function as the building blocks for traditional or advanced manufacturing techniques, while the high coercivity enables consistent performance across a wide range of temperatures

RSC Advances published new progress about Block construction materials. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics