Month: November 2022

Tian, Lu; Zhang, Luxin; Liu, Yuting; He, Yunfei; Zhu, Yujie; Sun, Ruijun; Yi, Simin; Xiang, Junping published the artcile< Clean production of ethyl levulinate from kitchen waste>, Product Details of C19H34O2, the main research area is kitchen waste ethyl levulinate heterogeneous catalyst physicochem property.

A clean and highly efficient catalytic system for the synthesis of Et levulinate (EL) from kitchen waste was developed. A heterogeneous catalyst (Sn/ZrP-SO3H) was prepared and the Bronsted and Lewis acid sites on the surface of the catalyst were evaluated by pyridine FT-IR. Other physicochem. properties were also characterized using XRD, SEM, FT-IR, XPS, BET, NH3-TPD. The yield of EL obtained was 49.27%, when glucose was used as the starting material and subjected to 170°C for 10 h in the presence of the solid acid catalyst, Sn/ZrP-SO3H. The prepared catalyst was also combined with several metal triflates; (Al(OTf)3, Fe(OTf)3, Sm(OTf)3) to form a catalytic system for the efficient preparation of EL from kitchen waste. Sn/ZrP-SO3H/Al(OTf)3 had superior activity compare to other catalyst combinations. In single factor experiments, the yield of EL reached 52.52% after heating at 170°C for 4 h. In addition, four-factor and three-level experiments were performed using response surface methodol. (RSM) to analyze the interaction between each factor. The optimal reaction conditions predicted by the model (163°C, 7.63 h, 20 mg Al(OTf)3, 40 mg Sn/ZrP-SO3H and 79.98 mg of kitchen waste) estimated a maximal yield for EL of 51.24%. The exptl. yield of EL however was 52.03% which confirms the reliability of the model. This work provides a cleaner production technol. for the synthesis of the high value-added chem. EL, and a sustainable route for the utilization of kitchen waste.

Journal of Cleaner Production published new progress about Polymer surface morphology. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

De Angelis, Martina; Primitivo, Ludovica; Lucarini, Claudia; Agostinelli, Sonia; Sappino, Carla; Ricelli, Alessandra; Righi, Giuliana published the artcile< Stereocontrolled total synthesis of iminosugar 1,4-dideoxy-1,4-imino-D-iditol>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is alditol iminosugar potential antiviral antitumor antidiabetic antituberculosis antibacterial alkaloid; iminosugar deoxyiminoiditol alditol preparation stereoselective hydroxylation deoxyiminogalactitol; 1,4-Dideoxy-1,4-imino-D-galactitol; 1,4-Dideoxy-1,4-imino-D-iditol; Asymmetric dihydroxylation; Iminosugars.

The first stereocontrolled total synthesis of iminosugar 1,4-dideoxy-1,4-imino-D-iditol is described. The key step in our approach was the double diastereo-selection in the asym. dihydroxylation (AD) of suitable optically active olefin, the chiral vinyl azido alc. Performing the AD using the most common Cinchona alkaloids as ligands enabled us to identify the ligand of choice for the stereodivergent synthesis of 1,4-dideoxy-1,4-imino-D-iditol and 1,4-dideoxy-1,4-imino-D-galactitol. These type of iminosugars, both natural and unnatural, are intensively studied for their promising chemotherapeutic properties against viral infections, diabetes, cancer, and tuberculosis.

Carbohydrate Research published new progress about Alditols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Qiu, Xiaoguang; Chen, Yidong; Bao, Zhaoshi; Chen, Li; Jiang, Tao published the artcile< Chemoradiotherapy with temozolomide vs. radiotherapy alone in patients with IDH wild-type and TERT promoter mutation WHO grade II/III gliomas: A prospective randomized study>, Reference of 112-63-0, the main research area is glioma temozolomide isocitrate dehydrogenase chemoradiotherapy radiotherapy mutation survival; Grade II/III glioma; IDH mutation; Radiotherapy; TERT promoter mutation; Temozolomide.

Patients with grade II/III diffuse glioma (lower grade glioma, LGG) with isocitrate dehydrogenase wild-type (IDH-wt) and telomerase reverse-transcriptase promoter mutation (TERTp-mut) experience shorter overall survival (OS) time than IDH mutant patients. The optimal treatment strategy for these patients is unclear. We compared the effects of radiotherapy (RT) alone vs. RT concurrent with temozolomide (TMZ) followed by adjuvant TMZ in these LGG patients.Thirty-seven LGG patients with IDH-wt and TERTp-mut were randomly allocated to either RT alone treatment (RT group, n = 18; 60 Gy in 30 daily fractions) or RT concurrent with TMZ (75 mg/m2/d, 7 d/wk) followed by adjuvant TMZ (CRT group, n = 19). The median follow-up duration was 17 mo. Log-rank test was used for OS and PFS comparisons.The 1-yr OS rate was 94.1[95confidence interval (CI) 82.9-100] in the CRT group and 74.6(95CI, 52.9-96.4) in the RT group. The median OS values in the CRT and RT groups were statistically different [25 vs. 17 mo, resp.; hazard ratio (HR) 0.271; 95CI, 0.092-0.793; P = 0.017], while PFS values were not (16 vs. 7 mo, resp.; HR, 0.917; 95CI, 0.397-2.120; P = 0.840). Multivariate anal. indicated that CRT treatment and female sex were associated with significantly longer OS (P = 0.001, P = 0.016, resp.).CRT treatment for IDH-wt/TERTp-mut grade II/III gliomas resulted in significantly longer OS than RT alone. Female sex was a significant favorable prognostic factor.

Radiotherapy and Oncology published new progress about Chemoradiotherapy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reddy, B. V. Subba; Babu, R. Anji; Ramana Reddy, M.; Reddy, B. Jagan Mohan; Sridhar, B. published the artcile< Intramolecular C-O/C-S bond insertion of α-diazoesters for the synthesis of 2-aryl-4H-benzo[d][1,3]oxazine and 2-aryl-4H-benzo[d][1,3]thiazine derivatives>, Electric Literature of 30095-98-8, the main research area is arylbenzoxazine carboxylate preparation; arylbenzothiazine carboxylate preparation; arylamidophenyl diazoacetate copper triflate catalyst intramol cyclization; arylthioamidophenyl diazoacetate copper triflate catalyst intramol cyclization.

An intramol. C-O insertion of 2-(2-arylamidophenyl)-2-diazoacetate was achieved using a catalytic amount of copper triflate under mild conditions to produce 2-aryl-4H-benzo[d][1,3]oxazine-4-carboxylate in good yields. In addition, 2-diazo-2-(2-arylthioamidophenyl)acetate afforded the corresponding 2-aryl-4H-benzo[d][1,3]thiazine derivatives under similar conditions. This was the first example of the synthesis of benzoxazines and benzothiazines from ortho-amidophenyl diazoacetate and ortho-thioamidophenyl diazoacetate, resp.

RSC Advances published new progress about Aromatic amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Electric Literature of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Campianl, Jian L.; Ghosh, Subhajit; Kapoor, Vaishali; Yan, Ran; Thotala, Sukrutha; Jash, Arijita; Hu, Tong; Mahadevan, Anita; Rifai, Kasem; Pagel, Logan; Lee, Byung Ha; Ferrando-Martinez, Sara; Wolfarth, Alexandra A.; Yang, Se Hwan; Hallahan, Dennis; Chhedau, Milan G.; Thotala, Dinesh published the artcile< Long-acting recombinant human interleukin-7, NT-17, increases cytotoxic CD8 T cells and enhances survival in mouse glioma models>, Category: esters-buliding-blocks, the main research area is temozolomide NT17 anticancer agent CD8 T cell glioblastoma.

Patients with glioblastoma (GBM) are treated with radiotherapy (RT) and temozolomide (TMZ). These treatments may cause prolonged systemic lymphopenia, which itself is associated with poor outcomes. NT-17 is a long-acting IL7 that expands CD4 and CD8 T-cell numbers in humans and mice. We tested whether NT-17 prevents sys- temic lymphopenia and improves survival in mouse models of GBM. Exptl. Design: C57BL/6 mice bearing intracranial tumors (GL261 or CT2A) were treated with RT (1.8 Gy/day x 5 days), TMZ (33 mg/kg/day x 5 days), and/or NT-17 (10 mg/kg on the final day of RT). We followed the mice for survival while serially analyzing levels of circulating T lymphocytes. We assessed regulatory T cells (Treg) and cytotoxic T lymphocytes in the tumor microenvironment, cervical lymph nodes, spleen, and thymus, and hematopoietic stem and progenitor cells in the bone marrow. GBM tumor-bearing mice treated with RT+NT-17 increased T lymphocytes in the lymph nodes, thymus, and spleen, enhanced Wily production, and decreased Tregs in the tumor which was associated with a significant increase in sur- vival. NT-17 also enhanced central memory and effector memory CD8 T cells in lymphoid organs and tumor. Depleting CD8 T cells abrogated the effects of NT-17. Furthermore, NT-17 treatment decreased progenitor cells in the bone marrow. In orthotopic glioma-bearing mice, NT-17 miti- gates RT-related lymphopenia, increases cytotoxic CD8 T lympho- cytes systemically and in the tumor, and improves survival. A phase I/II trial to evaluate NT-17 in patients with high-grade gliomas is ongoing (NCT03687957).

Clinical Cancer Research published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Boebel, Timothy A.; Hartwig, John F. published the artcile< Iridium-Catalyzed Preparation of Silylboranes by Silane Borylation and Their Use in the Catalytic Borylation of Arenes>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is iridium catalyzed silylborane preparation; silane borylation methoxy iridium cyclooctadiene butylbipyridine catalyzed; silylborane preparation catalytic borylation arene; arene carbon hydrogen bond activation.

Silylboranes are versatile reagents for transition metal-catalyzed reactions of unsaturated organic mols. These reagents are typically prepared by the addition of a silyl lithium species to a boron electrophile. However, the need to generate anionic silane reagents limits the scope of silylboranes that can be readily obtained. Here, the synthesis of trialkylsilylboranes by borylation of silanes catalyzed by iridium complexes is described. The reaction of trialkylhydrosilanes with B2pin2 catalyzed by the combination of [Ir(OMe)cod]2 and 4,4′-di-tert-butylbipyridine forms trialkylsilylboronic esters. In addition, these trialkylsilylboranes serve as boron sources for iridium-catalyzed borylation of aryl C-H bonds. In contrast to diboron reagents, the silylboranes react with methylarenes at both the aryl and Me C-H bonds.

Organometallics published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Shenlin; Voigtritter, Karl R.; Unger, John B.; Lipshutz, Bruce H. published the artcile< Asymmetric CuH-catalyzed 1,4-reductions in water at room temperature>, Application of C19H34O2, the main research area is Michael acceptor asym hydrosilylation copper hydride catalyst micelle water; alkene enantioselective reduction copper hydride catalyst micelle water.

Taking advantage of micellar catalysis in water, asym. hydrosilylation reactions of β,β-disubstituted Michael acceptors were conducted at ambient temperatures using water, and only water, as the global medium.

Synlett published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent) (Michael acceptors). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gue, Anne-Marie; Lattes, Armand; Laurent, Elisabeth; Mauzac, Monique; Mingotaud, Anne-Francoise published the artcile< Characterization of recognition sites for diethyl 4-nitrobenzylphosphonate, an organophosphate pesticide analogue>, SDS of cas: 112-63-0, the main research area is diethyl nitrobenzylphosphonate complexing fluoroalc aromatic acid recognition site.

In a first step towards developing chem. sensors using mol. imprinted materials, the complexing characteristics of di-Et 4-nitrobenzylphosphonate, an organophosphate pesticide analog, have been studied. Two mols. have been assessed as potential interacting moieties, specifically 1,1,1-trifluoro-2-(trifluoromethyl)pent-4-en-2-ol and 4-(3-butenyloxy)benzoic acid. The interactions have been first characterized by regular methods, such as 1H, 31P NMR and IR spectroscopy. These showed a stoichiometry 1/1 for both complexes and association constants 40 ± 10 and 12 ± 2 M-1, resp. In a second step, isothermal titration calorimetry was used and a method was developed to obtain low-association constants The association constant for the fluoroalc. ligand was 63 ± 0.7 M-1. For the benzoic acid derivative, an appropriate model could not be found, preventing the evaluation of this constant

Analytica Chimica Acta published new progress about Sensors. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Im, Eun-Ju; Lee, Chan-Hyeong; Moon, Pyong-Gon; Rangaswamy, Gunassekaran Gowri; Lee, Byungheon; Lee, Jae Man; Lee, Jae-Chul; Jee, Jun-Goo; Bae, Jong-Sup; Kwon, Taeg-Kyu; Kang, Keon-Wook; Jeong, Myeong-Seon; Lee, Joo-Eun; Jung, Hyun-Suk; Ro, Hyun-Joo; Jun, Sangmi; Kang, Wonku; Seo, Seung-Yong; Cho, Young-Eun; Song, Byoung-Joon; Baek, Moon-Chang published the artcile< Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A>, Category: esters-buliding-blocks, the main research area is sulfisoxazole anticancer agent breast cancer metastasis.

Inhibitors of the secretion of cancer exosomes, which promote cancer progression and metastasis, may not only accelerate exosome biol. research but also offer therapeutic benefits for cancer patients. Here we identify sulfisoxazole (SFX) as an inhibitor of small extracellular vesicles (sEV) secretion from breast cancer cells through interference with endothelin receptor A (ETA). SFX, an FDA-approved oral antibiotic, showed significant anti-tumor and anti-metastatic effects in mouse models of breast cancer xenografts, the reduced expression of proteins involved in biogenesis and secretion of sEV, and triggered co-localization of multivesicular endosomes with lysosomes for degradation We demonstrate the important role of ETA, as target of SFX, by gain- and loss-of-function studies of the ETA protein, through a direct binding assay, and pharmacol. and genetic approaches. These findings may provide a foundation for sEV-targeted cancer therapies and the mechanistic studies on sEV biol.

Nature Communications published new progress about Animal gene, CCL2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Paterson, Ian; Findlay, Alison D.; Noti, Christian published the artcile< Total synthesis of (-)-spirangien A, an antimitotic polyketide isolated from the myxobacterium Sorangium cellulosum>, SDS of cas: 617-55-0, the main research area is spirangien A preparation polyketide antimitotic antitumor agent asym synthesis.

An expedient first total synthesis of (-)-spirangien A, a potent cytotoxic and antifungal polyketide of myxobacterial origin, is described. A method for the synthesis of the title compound is reported here. By using a common 1,3-diol intermediate obtained by an efficient aldol-reduction sequence for installation of the C15-C18 and C25-C28 stereotetrads and a reagent-controlled boron aldol coupling followed by spiroacetalization, a highly convergent strategy was developed for construction of the elaborate spiroacetal core. Conversion of this advanced spiroacetal intermediate into (+)-spirangien diene, obtained previously by controlled degradation of spirangien A, was then achieved by installation of the truncated side-chain using an allylboration-Peterson sequence. The total synthesis of (-)-spirangien A was then achieved by the controlled attachment of the unsaturated C1-C12 side-chain, avoiding exposure to light. A Stork-Wittig olefination and double Stille cross-coupling sequence was exploited to install a delicate conjugated pentaene chromophore featuring alternating (Z)- and (E)-olefins, leading initially to the Me ester of spirangien A, which proved significantly more stable than the corresponding free acid. Subsequent careful hydrolysis afforded (-)-spirangien A. validating the relative and absolute configuration.

Chemistry – An Asian Journal published new progress about Absolute configuration. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, SDS of cas: 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics