Sinsheimer, J. E. published the artcileThe genotoxicity of enantiomeric aliphatic epoxides, Recommanded Product: (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, the publication is Mutation Research, Genetic Toxicology Testing (1993), 298(3), 197-206, database is CAplus and MEDLINE.
The (R)- and (S)-optical isomers of 9 epoxides, benzyloxymethyloxirane, epichlorohydrin, glycidol, glycidyl 3-nitrobenzenesulfonate, glycidyl 4-nitrobenzoate, glycidyl tosylate, styrene oxide, glycidyl 1-naphthyl ether, and glycidyl 4-nitrophenyl ether, were compared for their in vivo and in vitro genotoxicity. Differences in mutagenicity between isomers were established with Salmonella TA100 for all the compounds While 13 of the isomers were genotoxic compared to a neg. control by chromosomal aberration measurements, only in the case of glycidyl 4-nitrobenzoate could a significant difference be found between isomers by this test. However, with sister chromatid exchange evaluations, differences were detected between the (R)- and (S)-isomers for all the pairs of compounds with the exception of those for benzyloxymethyloxirane and glycidyl 4-nitrophenyl ether. At least in part, differences in the patterns of genotoxicity among compounds can be related to their differences in reaction pathways.
Mutation Research, Genetic Toxicology Testing published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C20H28B2O4S2, Recommanded Product: (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate.
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