Reddy Guduru, Shiva Krishna published the artcileSynthesis of Enantiomerically Pure 3-Substituted Piperazine-2-acetic Acid Esters as Intermediates for Library Production, Application In Synthesis of 106391-88-2, the publication is Journal of Organic Chemistry (2018), 83(19), 11777-11793, database is CAplus and MEDLINE.
Differentially protected 2,3-disubstituted piperazineacetates such as I and II (R = Me, PhCH2, i-Bu; Ns = 2-O2NC6H4SO2; Boc = t-BuO2C) were prepared for potential use in the synthesis of piperidine-containing combinatorial libraries. The piperazineacetates were prepared from L- or D-amino acids by acid reduction, oxidation and stereoselective Wittig olefination, Michael addition, amine protection with NsCl, cyclocondensation, and Boc deprotection and reprotection; the diastereomeric piperazines were separated Twenty monoprotected chiral 2,3-disubstituted piperazines, were prepared as single absolute stereoisomers; all but one were prepared in multigram quantities.
Journal of Organic Chemistry published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C10H19NO3, Application In Synthesis of 106391-88-2.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics