Lin, Hsi-Hsin published the artcileSelective Ammonolysis of Bioderived Esters for Biobased Amide Synthesis, Product Details of C8H14O4, the publication is ACS Omega (2021), 6(44), 30040-30049, database is CAplus and MEDLINE.
Amidation is an important reaction for bioderived platform mols., which can be upgraded for use in applications such as polymers. However, fundamental understanding of the reaction especially in the presence of multiple groups is still lacking. In this study, the amidation of di-Me fumarate, maleate, and succinate through ester ammonolysis was examined The reaction networks and significant side reactions, such as conjugate addition and ring closing, were determined A preliminary kinetic comparison among addnl. C4 and C6 esters showed a significant correlation between mol. structure and ammonolysis reactivity. Esters with a C=C double bond in the mol. backbone were found to have higher ammonolysis reactivity. To improve the selectivity to unsaturated amides rather than byproducts, the effects of thermal conditions and additives in di-Me fumarate ammonolysis were examined Lower temperature and decreasing methoxide ion concentration in the solution relative to the base case conditions increased the fumaramide selectivity from 67.1 to 90.6%.
ACS Omega published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, Product Details of C8H14O4.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics