Han, Junyong published the artcileExperimental study on the effect of dimethyl itaconate on insulitis in non-obese diabetic mice, Formula: C7H10O4, the publication is Fujian Yiyao Zazhi (2021), 43(6), 122-125, database is CAplus.
Objective To investigate the effect of di-Me itaconate on insulitis in NOD mice. Methods The phenotypic changes of RAW 264.7 macrophages induced by di-Me itaconate were detected by flow cytometry, and the effect of di-Me itaconate on the secretion of RAW 264.7 cytokines (IL-6, IL-12 and TNF-α) were observed by ELISA. At the same time, di-Me itaconate was injected i.p. into NOD mice to further explore its effect on islet inflammation. Results Di-Me itaconate reduced the M1/M2 ratio of macrophages and converted macrophages to M2 type, and also reduced the secretion of IL-6, IL-12 and TNF-α. The islet score of 50 mg/kg di-Me itaconate reached 1.115±0.7821. Conclusion Di-Me itaconate can alleviate insulitis in NOD mice by phenotypic transformation of M1/M2 macrophages.
Fujian Yiyao Zazhi published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Formula: C7H10O4.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics