Chen, Ke-Wei published the artcileOrganocatalytic Atroposelective Synthesis of N-N Axially Chiral Indoles and Pyrroles by De Novo Ring Formation, HPLC of Formula: 30414-53-0, the publication is Angewandte Chemie, International Edition (2022), 61(17), e202116829, database is CAplus and MEDLINE.
The first highly atroposelective construction of N-N axially chiral indole scaffolds I [R = H, 4-F, 6-MeO, 7-Br, etc.; R1 = H, Me; R2 = CO2Me, CO2Et, Ph, etc.; R3 = Me, Et, i-Pr, Bn; R4 = Ph, 2-FC6H4, 3-FC6H4, etc.] was established via a new strategy of de novo ring formation. This strategy made use of the organocatalytic asym. Paal-Knorr reaction of well-designed N-aminoindoles with 1,4-diketones, thus affording N-pyrrolylindoles in high yields and with excellent atroposelectivities (up to 98% yield, 96% ee). In addition, this strategy was applicable for the atroposelective synthesis of N-N axially chiral bispyrroles II [R5 = Ph, 3-ClC6H4, 3-MeOC6H4, 1-naphthyl, 2-naphthyl; R6 = Me, Et, Bn; R7 = Me, Et, i-Pr; R8 = Ph, 2-FC6H4, 3-thienyl, etc.; R9 = Me, Et, i-Pr, Bn] (up to 98% yield, 97% ee). More importantly, such N-N axially chiral heterocycles could be converted into chiral organocatalysts with applications in asym. catalysis, and some mols. display potent anticancer activity. This work not only provided a new strategy for the atroposelective synthesis of N-N axially chiral mols. but also offers new members of the N-N atropisomer family with promising applications in synthetic and medicinal chem.
Angewandte Chemie, International Edition published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, HPLC of Formula: 30414-53-0.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics