A smart O2-generating nanocarrier optimizes drug transportation comprehensively for chemotherapy improving was written by Zhang, Xiaojuan;He, Chuanchuan;Sun, Yun;Liu, Xiaoguang;Chen, Yan;Chen, Chen;Yan, Ruicong;Fan, Ting;Yang, Tan;Lu, Yao;Luo, Jun;Ma, Xiang;Xiang, Guangya. And the article was included in Acta Pharmaceutica Sinica B in 2021.Computed Properties of C21H44O5 The following contents are mentioned in the article:
Drug transportation is impeded by various barriers in the hypoxic solid tumor, resulting in compromised anticancer efficacy. Herein, a solid lipid monostearin (MS)-coated CaO2/MnO2 nanocarrier was designed to optimize doxorubicin (DOX) transportation comprehensively for chemotherapy enhancement. The MS shell of nanoparticles could be destroyed selectively by highly-expressed lipase within cancer cells, exposing water-sensitive cores to release DOX and produce O2. After the cancer cell death, the core-exposed nanoparticles could be further liberated and continue to react with water in the tumor extracellular matrix (ECM) and thoroughly release O2 and DOX, which exhibited cytotoxicity to neighboring cells. Small DOX mols. could readily diffuse through ECM, in which the collagen deposition was decreased by O2-mediated hypoxia-inducible factor-1 inhibition, leading to synergistically improved drug penetration. Concurrently, DOX-efflux-associated P-glycoprotein was also inhibited by O2, prolonging drug retention in cancer cells. Overall, the DOX transporting processes from nanoparticles to deep tumor cells including drug release, penetration, and retention were optimized comprehensively, which significantly boosted antitumor benefits. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Computed Properties of C21H44O5).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Computed Properties of C21H44O5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics