Shahab, Mohammed Shadab et al. published their research in Journal of Drug Delivery Science and Technology in 2022 | CAS: 31566-31-1

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application of 31566-31-1

Formulation, optimization and evaluation of vitamin E TPGS emulsified dorzolamide solid lipid nanoparticles was written by Shahab, Mohammed Shadab;Rizwanullah, Md;Sarim Imam, Syed. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Application of 31566-31-1 The following contents are mentioned in the article:

Herein, we designed this research to develop dorzolamide (DRZ) encapsulated solid lipid nanoparticles (SLNs) for ocular administration. The DRZ-SLNs were fabricated by ultrasonic emulsification method and optimized statistically by Box-Behnken design (3 factors at three levels BBD). Glyceryl monostearate (GMS; A), D-a-Tocopherol polyethylene glycol 1000 succinate (TPGS; B), and sonication time (ST; C) were chosen as independent variables while particles size (PS; R1), polydispersity index (PDI; R2), and encapsulation efficiency (EE%; R3) were selected as dependent variables/responses. The optimized DRZ-SLNs showed the PS, PDI, and EE of 175.38 ± 5.42 nm, 0.19 ± 0.05, and 80.47 ± 3.57%, resp. The optimized DRZ-SLNs represented initially fast release within 2 h and then a sustained release profile from 2 h to 10 h in simulated tear fluids (STF). DRZ-SLNs revealed 2.87-fold higher trans corneal permeation enhancement compared to DRZ solution Furthermore, HET-CAM study and the histopathol. study revealed that optimized DRZ-SLNs was found to be non-irritant and safe for ocular delivery. Therefore, it was concluded that the DRZ SLNs can be a promising and effective nanoplatform for ocular administration. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Application of 31566-31-1).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application of 31566-31-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics