Formulation and evaluation of Darunavir loaded solid lipid nanoparticles was written by Sandirigiri, Dinesh Kumar;Vijetha, K. Anie. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2022.Quality Control of Glyceryl monostearate The following contents are mentioned in the article:
Darunavir is an anti-retroviral drug and it is inhibitor of HIV protease with poor water solubility So, the main objective of the study is to improve the solubility and bioavailability of poor water soluble drug Darunavir. The Present study outlines the formulation of the Darunavir loaded solid lipid nanoparticles, Particle size anal., Surface morphol., dissolution studies, drug loading, entrapment efficiency and drug release kinetics along with mechanisms. In general, Solid lipid nanoparticles were prepared by using various methods like homogenization, ultrasonication. The Optimized Solid lipid nanoparticles formed with Darunavir resulted in particle size of 334 nm, Poly dispersity index (0.184), zeta potential (-12.75) which results in stable dispersion. In-vitro drug release studies in 6.8 PH phosphate buffer shown 91.2% drug release at the last time period of 12 h and followed zero order release kinetics. Differential Scanning Calorimetry Studies were performed and found no chem. interactions. Surface morphol. was studied by SEM anal. and found that particles with spherical shape and smooth surface were appeared. Accelerated stability studies which was performed at 25.30 and 400 C temperatures after 3 mo there was no change in the stability of dispersion upon storage conditions. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Quality Control of Glyceryl monostearate).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Quality Control of Glyceryl monostearate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics