Design and development of surface modified epigallocatechin 3-gallate NanoCubogel for localized delivery to oral submucous fibrosis therapy was written by Mehta, Chetan Hasmukh;Narayan, Reema;Acharya, Shruthi;Nayak, Usha Yogendra. And the article was included in Journal of Drug Delivery Science and Technology in 2021.Electric Literature of C21H44O5 The following contents are mentioned in the article:
The present study is aimed at the development of stearylamine (SA) modified epigallocatechin 3-gallate (EGCG) loaded NanoCubes incorporated in mucoadhesive hydrogel (NanoCubogel), for the local treatment of oral submucous fibrosis (OSF) owing to its anti-fibrotic, anti-inflammatory, and oxygen radical scavenging properties with a better safety profile. The prepared NanoCubes and mucoadhesive NanoCubogel were evaluated and characterized for various parameters including in-vitro release and ex-vivo permeation studies. The optimized NanoCubes had a particle size, polydispersity index, zeta potential, and entrapment efficiency of 140.3 ± 1.12 nm, 0.173± 0.08, 46.9 ± 1.69 mV, and 59.0 ± 1.73%, resp. with cube-shaped morphol. The viscosity of the NanoCubogel was found to be 9253 ±112 cps. The SA modified NanoCubogel showed slower and sustained release of EGCG with higher permeation across buccal mucosa when compared to that of unmodified and pure EGCG. The formulation was found to be stable during the storage period. The developed NanoCubogel was capable of getting retained at the diseased site for a longer duration and releasing the EGCG locally for the desired time. Thus, the developed formulation may be used as an alternative treatment for OSF. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Electric Literature of C21H44O5).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C21H44O5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics