Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery was written by Ho, Hoang Nhan;Le, Hoang Hao;Le, Thien Giap;Duong, Thi Hong Anh;Ngo, Viet Quynh Tram;Dang, Cong Thuan;Nguyen, Van Minh;Tran, Tuan Hiep;Nguyen, Chien Ngoc. And the article was included in International Journal of Biological Macromolecules in 2022.Reference of 31566-31-1 The following contents are mentioned in the article:
Local delivery of drug is a promising strategy to manage periodontitis characterized by chronic inflammation of the soft tissue surrounding the teeth. An optimized system should prolong the drug retention time and exhibit controlled drug permeation through the buccal mucosal layer. This study was aimed to develop hydroxyethyl cellulose (HEC)-based gel containing metronidazole (MTZ) loaded in solid lipid nanoparticles (SLNs), and to enhance the antimicrobial activity of MTZ. SLNs were prepared using a combination method of solvent evaporation and hot homogenization. The results showed that the fabricated SLNs, comprising of Precirol (2.93%, w/v), Tween 80 (1.8%, w/v), and the drug:lipid ratio of 19.3% (weight/weight), were approx. 200 nm in size, with a narrow distribution. The HEC (3%, weight/weight)-based gel formed a smooth, homogeneous structure and had preferable mech. and rheol. properties. Moreover, the MTZ-loaded SLNs-based HEC gel (equivalent to 1% of MTZ, weight/weight) exhibited a sustained in vitro drug release pattern, optimal ex vivo permeability, and enhanced in vitro antimicrobial activity after 24 h of treatment. These findings indicate the potential of the MTZ-loaded SLNs-based HEC formulation for local drug delivery at the buccal mucosa in managing periodontal disease. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Reference of 31566-31-1).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Reference of 31566-31-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics