Bosch, Joan published the artcileStereoselective Syntheses of the Antihistaminic Drug Olopatadine and Its E-Isomer, Application of Methyl 2-(3-formyl-4-hydroxyphenyl)acetate, the publication is Journal of Organic Chemistry (2012), 77(14), 6340-6344, database is CAplus and MEDLINE.
Practical stereoselective synthetic routes to the antihistaminic drug olopatadine (I) and its E-isomer have been developed, the key steps being a trans stereoselective Wittig olefination using a nonstabilized phosphorus ylide and a stereoselective Heck cyclization. The stereoselectivity of the Wittig reaction depends on both the phosphonium salt anion and the cation present in the base used to generate the ylide.
Journal of Organic Chemistry published new progress about 61874-04-2. 61874-04-2 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester,Aldehyde, name is Methyl 2-(3-formyl-4-hydroxyphenyl)acetate, and the molecular formula is C10H10O4, Application of Methyl 2-(3-formyl-4-hydroxyphenyl)acetate.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics