Solvent-induced membrane stress in biofuel production: molecular insights from small-angle scattering and all-atom molecular dynamics simulations was written by Smith, Micholas Dean;Pingali, Sai Venkatesh;Elkins, James G.;Bolmatov, Dima;Standaert, Robert F.;Nickels, Jonathan D.;Urban, Volker S.;Katsaras, John;Davison, Brian H.;Smith, Jeremy C.;Petridis, Loukas. And the article was included in Green Chemistry in 2020.COA of Formula: C39H76NO8P The following contents are mentioned in the article:
The disruptive effect of organic solvents on microbial membranes represents a significant challenge to the economical production of green fuels and value-added chems. from lignocellulosic feedstocks. One route to overcoming this challenge is to engineer microbes with membranes capable of resisting organic solvent stresses. In this regard, it is useful to understand the mechanisms by which organic solvents disrupt typical biomembranes. Here, mol. dynamics (MD) simulation, complemented by small-angle X-ray and neutron scattering (SANS/SAXS), provide a mol.-scale view of the disruption of a microbial model membrane by 1-butanol and THF (THF), two common water-organic cosolvent mixtures of importance in biofuel production Solvent interactions at the interface between the head-group and fatty acid tail regions lead to more dramatic membrane changes than interactions solely at the head-groups or tails. Although both organic solvents are found to partition into the membrane, the depth of solvent penetration into the membrane is quite different. Specifically, 1-butanol localizes near the interface between the lipid heads and tails at low concentrations, but partitions into both the head and tail regions at high concentrations In contrast, THF, overall, partitions less than 1-butanol and prefers the lipid tail regions. Importantly, the presence of 1-butanol near the head/tail interface introduces drastic membrane changes not seen with THF. The organic solvent interactions with the lipids lead to membrane thinning. This study involved multiple reactions and reactants, such as (2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2COA of Formula: C39H76NO8P).
(2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.COA of Formula: C39H76NO8P
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics