Catalyst-free Hydrophosphinylation of Isocyanates and Isothiocyanates under Low-Added-Solvent Conditions was written by Huke, Cameron D.;Taylor, Laurence J.;Argent, Stephen P.;Kays, Deborah L.. And the article was included in ACS Sustainable Chemistry & Engineering in 2021.Synthetic Route of C4H7NS The following contents are mentioned in the article:
Phosphinecarboxamides R1R2P(O)CXNHR3 (R1, R2 = Ph, iPr, OEt, OMe; R3 = aryl, iPr, tBu, n-Pr, C6H13, PhCH2, Cy, 2-furyl; X = O, S) were prepared by green, catalyst-free, low-solvent hydrophosphination of isocyanates R3N:C:X with secondary phosphine oxides and dialkyl phosphites R1R2P(O)H. A range of phosphorus nucleophiles including secondary phosphine oxides HP(O)R2 (R = Ph, iPr), phosphites HP(O)(OR)2 (R = Me, Et), and Me phenylphosphinate were tested. The procedure tolerated isocyanates and isothiocyanates featuring a wide range of substituents, and with use of 4 equiv of 2-methyltetrahydrofuran (2-MeTHF), solid substrates can be utilized. Twenty-five compounds were prepared, with improved functional group tolerance compared to previous methods allowing access to new compounds (16 are novel). Facile scale up and simple reaction conditions make this a straightforward and practical methodol. for obtaining phosphorus analogs of ureas and thioureas, which are challenging to synthesize by other methods. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Synthetic Route of C4H7NS).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Synthetic Route of C4H7NS
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics