Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines was written by Hassett, Kimberly J.;Benenato, Kerry E.;Jacquinet, Eric;Lee, Aisha;Woods, Angela;Yuzhakov, Olga;Himansu, Sunny;Deterling, Jessica;Geilich, Benjamin M.;Ketova, Tatiana;Mihai, Cosmin;Lynn, Andy;McFadyen, Iain;Moore, Melissa J.;Senn, Joseph J.;Stanton, Matthew G.;Almarsson, Orn;Ciaramella, Giuseppe;Brito, Luis A.. And the article was included in Molecular Therapy–Nucleic Acids in 2019.Computed Properties of C43H79NO2 The following contents are mentioned in the article:
MRNA vaccines have the potential to tackle many unmet medical needs that are unable to be addressed with conventional vaccine technologies. A potent and well-tolerated delivery technol. is integral to fully realizing the potential of mRNA vaccines. Pre-clin. and clin. studies have demonstrated that mRNA delivered i.m. (IM) with first-generation lipid nanoparticles (LNPs) generates robust immune responses. Despite progress made over the past several years, there remains significant opportunity for improvement, as the most advanced LNPs were designed for i.v. (IV) delivery of siRNA to the liver. Here, we screened a panel of proprietary biodegradable ionizable lipids for both expression and immunogenicity in a rodent model when administered IM. A subset of compounds was selected and further evaluated for tolerability, immunogenicity, and expression in rodents and non-human primates (NHPs). A lead formulation was identified that yielded a robust immune response with improved tolerability. More importantly for vaccines, increased innate immune stimulation driven by LNPs does not equate to increased immunogenicity, illustrating that mRNA vaccine tolerability can be improved without affecting potency. This study involved multiple reactions and reactants, such as (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate (cas: 1224606-06-7Computed Properties of C43H79NO2).
(6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate (cas: 1224606-06-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Computed Properties of C43H79NO2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics