Lipid Nanocarriers Overlaid with Chitosan for Brain Delivery of Berberine via the Nasal Route was written by Abo El-Enin, Hadel A.;Elkomy, Mohammed H.;Naguib, Ibrahim A.;Ahmed, Marwa F.;Alsaidan, Omar A.;Alsalahat, Izzeddin;Ghoneim, Mohammed M.;Eid, Hussein M.. And the article was included in Pharmaceuticals in 2022.Name: Glyceryl monostearate The following contents are mentioned in the article:
This research aimed to design, optimize, and evaluate berberine-laden nanostructured lipid carriers overlaid with chitosan (BER-CTS-NLCs) for efficient brain delivery via the intranasal route. The nanostructured lipid carriers containing berberine (BER-NLCs) were formulated via hot homogenization and ultrasonication strategy and optimized for the influence of a variety of causal variables, including the amount of glycerol monostearate (solid lipid), poloxamer 407 (surfactant) concentration, and oleic acid (liquid lipid) amount, on size of the particles, entrapment, and the total drug release after 24 h. The optimal BER-NLCs formulation was then coated with chitosan. Their diameter, in vitro release, surface charge, morphol., ex vivo permeability, pH, histol., and in vivo (pharmacokinetics and brain uptake) parameters were estimated BER-CTS-NLCs had a size of 180.9 ± 4.3 nm, sustained-release properties, pos. surface charge of 36.8 mV, and augmented ex-vivo permeation via nasal mucosa. The histopathol. assessment revealed that the BER-CTS-NLCs system is safe for nasal delivery. Pharmacokinetic and brain accumulation experiments showed that animals treated intranasally with BER-CTS-NLCs had substantially greater drug levels in the brain. The ratios of BER brain/blood levels at 30 min, AUCbrain/AUCblood, drug transport percentage, and drug targeting efficiency for BER-CTS-NLCs (IN) were higher compared to BER solution (IN), suggesting enhanced brain targeting. The optimized nanoparticulate system is speculated to be a successful approach for boosting the effect of BER in treating CNS diseases, such as Alzheimer’s disease, through intranasal therapy. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Name: Glyceryl monostearate).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Name: Glyceryl monostearate
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Ester – an overview | ScienceDirect Topics