Design expert assisted formulation, characterization and optimization of microemulsion based solid lipid nanoparticles of repaglinide was written by Maddiboyina, Balaji;Jhawat, Vikas;Nakkala, Ramya Krishna;Desu, Prasanna Kumar;Gandhi, Sivaraman. And the article was included in Progress in Biomaterials in 2021.Safety of Glyceryl monostearate The following contents are mentioned in the article:
Repaglinide, a member of the meglitinide class of drugs, is a new anti-diabetic agent that is utilized as an oral hypoglycemic agent. Using glyceryl monostearate, cetyl palmitate, and tristearin as lipids and poloxamer 188 as a surfactant, repaglinide-loaded solid lipid nanoparticles were created. Solid lipid nanoparticles were prepared utilizing an o/w microemulsion technique, which included the lipids glyceryl monostearate and tristearin, as well as waxes such as cetyl palmitate and the surfactant poloxamer 188. The mean particle size of the solid lipid nanoparticles formed was around 339 nm, with an entrapment efficiency of 82.20%. In-vitro release studies continued to be conducted using the dialysis bag diffusion technique. Within 12 h, the cumulative drug release was 88.4%. The results indicate that repaglinide was released more slowly from solid lipid nanoparticles made from tristearin and glyceryl monostearate in an equal ratio. Tristearin found the controlled release and extreme entrapment from other lipid carriers like glyceryl monostearate and cetyl palmitate. Differential scanning calorimetry demonstrates that repaglinide is entangled in amorphous or mol. state within solid lipid nanoparticles. SEM microscopy revealed that the produced repaglinide solid lipid nanoparticles had a spherical shape. After one month of storage at 2-8°C, short-term stability testing revealed no significant alteration. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Safety of Glyceryl monostearate).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Safety of Glyceryl monostearate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics