Jain, Atul et al. published their research in Drug Delivery and Translational Research in 2022 | CAS: 31566-31-1

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Reference of 31566-31-1

Raloxifene-loaded solid lipid nanoparticles with enhanced biopharmaceutical potential: Quality by design-steered development, in vitro evaluation, in vivo pharmacokinetics, and IVIVC was written by Jain, Atul;Sharma, Teenu;Kumar, Rajendra;Katare, O. P.;Singh, Bhupinder. And the article was included in Drug Delivery and Translational Research in 2022.Reference of 31566-31-1 The following contents are mentioned in the article:

Preparation of SLNs was carried out using glyceryl monostearate and Compritol 888 ATO (i.e., lipid), Phospholipid S-100 (i.e., co-surfactant), and TPGS-1000 (i.e., surfactant) employing solvent diffusion method. The optimized SLN formulations exhibited a mean particle size of 109.7 nm, PDI 0.289 with a zeta potential of -13.7 mV. In vitro drug dissolution studies showed Fickian release, with release exponent of 0.137. Cell cytotoxicity assay, apoptosis assay, and cellular uptake indicated 6.40-, 5.40-, and 3.18-fold improvement in the efficacy of RLX-SLNs vis-a-́vis pure RLX. Besides, the pharmacokinetic studies indicated quite significantly improved biopharmaceutical performance of RLX-SLNs vis-a-́vis pure drug, with 4.06-fold improvement in Cmax, 4.40-fold in AUC(0-72h), 4.56-fold in AUC(0-∞), 1.53-fold in Ka, 2.12-fold in t1/2, and 1.22-fold in Tmax. For RLX-SLNs and pure drug, high degree of level A linear correlation was established between fractions of drug dissolved (in vitro) and of drug absorbed (in vivo) at the corresponding time-points. Stability studies indicated the robustness of RLX-SLNs when stored at for 3 mo. Results obtained from the different studies construe promising the anticancer potential of the developed RLX-SLNs, thereby ratifying the lipidic nanocarriers as an efficient drug delivery strategy for improving the biopharmaceutical attributes of RLX. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Reference of 31566-31-1).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Reference of 31566-31-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics