Design, Synthesis, and Evaluation of Novel 2H-Benzo[b][1,4]thiazin-3(4H)-one Derivatives as New Acetylcholinesterase Inhibitors was written by Haji Ali, Sazan;Osmaniye, Derya;Saglik, Begum Nurpelin;Levent, Serkan;Ozkay, Yusuf;Kaplancikli, Zafer Asim. And the article was included in Molecules in 2022.Name: Isopropylisothiocyanate The following contents are mentioned in the article:
Alzheimer’s disease (AD) is a slowly progressive neurodegenerative disease that causes dementia in people aged 65 and over. In the present study, a series of thiadiazole hybrid compounds with benzothiazine derivatives I (R = Et, Pr, t-Bu, etc.) as acetylcholinesterase inhibitors were developed and evaluated for their biol. activity. The AChE and BChE inhibition potentials of all compounds were evaluated by using the in vitro Ellman method. The biol. evaluation showed that compounds I (R = 4-OMeC6H4) and I (R = 4-ClC6H4) displayed significant inhibitory activity against AChE and showed IC50 values of 0.027μM and 0.025μM against AChE, resp. The reference drug donepezil (IC50 = 0.021μM) also showed significant inhibition against AChE. Further docking simulation also revealed that the above compounds interacted with the active site of the enzyme similarly to donepezil. The antioxidant study revealed that the above two compounds exhibited greater antioxidant effects. An in vitro blood-brain barrier permeability study showed that compounds I (R = 4-OMeC6H4) and I (R = 4-ClC6H4) are promising compounds against AD. The cytotoxicity study of the above compounds showed non-cytotoxic with an IC50 value of 98.29 ± 3.98μM and 159.68 ± 5.53μM against NIH/3T3 cells, resp. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Name: Isopropylisothiocyanate).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: Isopropylisothiocyanate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics