Intranasal repaglinide-solid lipid nanoparticles integrated in situ gel outperform conventional oral route in hypoglycemic activity was written by Elkarray, Soha M.;Farid, Ragwa M.;Abd-Alhaseeb, Mohammad M.;Omran, Gamal A.;Habib, Doaa A.. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Recommanded Product: Glyceryl monostearate The following contents are mentioned in the article:
Repaglinide (REP) loaded solid-lipid nanoparticles (SLNs) for intranasal administration is the subject of the current work aiming enhancement of diabetes pharmacotherapy. SLNs were prepared by applying 32 factorial-design using the hot-melt emulsion technique. Surfactant and lipid types were selected as the independent variables. The optimized formula composed of glyceryl monostearate and Poloxamer 188 was further integrated into gellan gum (GG 0.5%w/v) in situ gel for ease of administration. The optimized SLNs integrated into situ gel (SLNF1.ISG0.5) showed small particle size (96.34nm), high EE (80.57%), and outstanding sustained release of only 83.3% after 30h. ISG formula showed pseudo-plastic behavior, mucoadhesive property, and phys. stablility. TEM showed spherical nanoparticles associated with the hydrogel matrix. In vivo pharmacodynamic study results in diabetic rats’ proved to be safe and succeeded to show superior hypoglycemic-activity for REP after nasal administration vs. oral route manifested by higher 1.2-fold % maximum reduction, the 2.5-fold total decrease in blood glucose level with a significantly longer duration of action > 48h. Conclusively, the developed intranasal drug-loaded-SLNs integrated in-situ gel formula succeeded to achieve the maximum therapeutic outcome of repaglinide in dose reduction frequency for diabetes mellites treatment. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Recommanded Product: Glyceryl monostearate).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: Glyceryl monostearate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics