Amin, Sk. Abdul published the artcileDevelopment of decision trees to discriminate HDAC8 inhibitors and non-inhibitors using recursive partitioning, Application of (Pivaloyloxy)methyl butyrate, the publication is Journal of Biomolecular Structure and Dynamics (2021), 39(1), 1-8, database is CAplus and MEDLINE.
Histone deacetylase 8 (HDAC8) is involved in malignancy. Overexpression of HDAC8 is correlated with various cancers. Design of selective HDAC8 inhibitors is always a challenging task to the chem. audiences. In this communication, a diverse set comprising large number of compounds are subjected to recursive partitioning (RP) anal. to develop decision trees to discriminate compounds into HDAC8 inhibitors (active) and non-inhibitors (inactive). Acquiring knowledge about the essential structural and physicochem. parameters can be useful in designing potential and selective HDAC8 inhibitors. Moreover, this work validates our previous results observed in Bayesian modeling study of this dataset.
Journal of Biomolecular Structure and Dynamics published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Application of (Pivaloyloxy)methyl butyrate.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics