Al-Hiari, Yusuf M. published the artcileSynthesis and antibacterial properties of new 8-nitrofluoroquinolone derivatives, Related Products of esters-buliding-blocks, the publication is Molecules (2007), 12(6), 1240-1258, database is CAplus and MEDLINE.
A series of new 8-nitrofluoroquinolone derivatives has been prepared to study their antibacterial properties. The work initially involved large scale preparation of the synthon 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid followed by introduction of substituted primary amine appendages at the C-7 position to give amino derivatives, e.g., I (R = H, Me, Cl), using anilines, 2-aminopyridines, and other primary amines. This nucleophilic aromatic substitution step was a very simple procedure since the 8-nitro group of the above synthon facilitated the addition of weak nucleophiles at C-7. The prepared targets and the intermediates have shown interesting antibacterial activity against gram pos. and/or gram neg. strains. In particular, the p-toluidine, p-chloroaniline and aniline derivatives showed good activity against S. aureus with MIC range ≈ 2-5 μg/mL. In conclusion, more lipophilic groups seem to enhance activity against gram pos. strains.
Molecules published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Related Products of esters-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics