Experimental and computational insight of the supramolecular complexes of Irbesartan with 尾-cyclodextrin based nanosponges was written by Suvarna, Vasanti;Singh, Vikas;Sharma, Dhvani;Murahari, Manikanta. And the article was included in Journal of Drug Delivery Science and Technology in 2021.Product Details of 102-09-0 The following contents are mentioned in the article:
Irbesartan (IRB), one of the extensively prescribed drugs, for treatment of hypertension has limited therapeutic potential attributed to its poor water solubility, slow dissolution rate and poor bioavailability. Cyclodextrin-based nanosponges (NSs) are novel nanosized delivery systems comprised of hyper-crosslinked solid nanoparticles with nanosized cavities. Nanosponges are widely explored to increase water solubility of active drug moieties, to protect labile actives, to achieve prolonged or sustained release and site-specific targeting. The aim of the study was to investigate enhancement of solubility of Irbesartan by its complexation with 尾-cyclodextrin (尾-CD) based nanosponges (NS). Blank NSs were fabricated by reacting 尾-CD, with pyromellitic dianhydride (PMDA) and di-Ph carbonate (DPC) as crosslinkers, in various molar ratios of 1:2, 1:4, 1:6 and 1:8. Solubility studies were performed to select drug nanosponge stoichiometric complex with highest degree of saturation solubilization. Irbesartan loaded nanosponges namely PMDA-CDNS and DPC-CDNS were prepared and characterized by differential scanning calorimetry, Fourier transform IR spectroscopy, powd. X-ray diffraction, SEM and NMR studies, to confirm the complexation of Irbesartan with nanosponges. PXRD studies revealed the shift from crystalline nature of Irbesartan to amorphous form in nanoponges. The average particle sizes of IRB-PMDA-CDNS and IRB-DPC-CDNS were 471.5 nm and 382.7 nm resp. Zeta Potential values were 34.9 mV and -29mV for IRB-PMDA-CDNS and IRB- DPC-CDNS resp. Entrapment efficiency varied from 9 to 38% weight/weight and 17 to 33%weight/weight for IRB-PMDA-CDNS and IRB-DPC-CDNS resp. Complexation of IRB with 尾-cyclodextrin based nanosponges, as IRB-PMDA-CDNS and IRB-DPC-CDNS, resulted in significant enhancement of 81.86 and 23.35 folds, in its water solubility and 1.91- and 1.96-folds enhancement in its percent dissolution efficiency (% D.E.) resp. Mol. docking calculations of IRB with DPC-CDNS and PMDA-CDNS have exhibited binding affinities of -8.97 and -9.51 kcal/mol resp. Mol. dynamics simulations have revealed that IRB with PMDA-CDNS is more stable and efficient nanocarrier. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0Product Details of 102-09-0).
Diphenyl carbonate (cas: 102-09-0) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Product Details of 102-09-0
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics