Intranasal delivery of chitosan decorated nanostructured lipid carriers of Buspirone for brain targeting: Formulation development, optimization and In-Vivo preclinical evaluation was written by Noorulla, K. M.;Yasir, Mohd;Muzaffar, Faizi;S, Roshan;Ghoneim, Mohammed M.;Almurshedi, Alanood S.;Tura, Abdurazak J.;Alshehri, Sultan;Gebissa, Teshome;Mekit, Shimelis;Ahmed, Mohammed Muqtader;Zafar, Ameeduzzafar. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Related Products of 31566-31-1 The following contents are mentioned in the article:
The current research was portrayed to design and optimize the Chitosan (CH) coated Buspirone-loaded nanostructured lipid carriers (BPE-CH-NLCs) for nose to brain delivery. NLCs were developed by solvent diffusion evaporation technique, coated with CH, and then optimized to the maximum efficiency using the quality by design (QbD) based Box-Behnken design (BBD). Glyceryl monostearate (GMS) & oleic acid mixture and tween 80 were used as a lipid and surfactant, resp. The prepared NLCs were subjected to in-vitro characterization. In-vivo pharmacokinetic and neuro-pharmacokinetic (drug targeting efficiency-DTE, direct transport percentage-DTP) parameters were evaluated on Wister rats. The results revealed that the optimized formulation exhibited acceptable PS (190.98 卤 4.72 nm), ZP (+17.47 mV), and EE (80.53 卤 1.26% weight/weight), and the TEM image showed that the drug was incorporated adequately in NLCs. DSC findings exposed that the drug was present in amorphous form within the NLCs. The optimized formulation exhibited 27.61 mo shelf life and was found to be stable under studied conditions. The value of AUC (bioavailability) for BPE-CH-NLCs administered i.n was found to be 3.06 folds compared to BPE-CH-NLCs administered i.v, and 2.17 folds compared to BPE-Sol administered i.n. A higher value of DTE (1462.49%) for developed NLCs confirmed the brain targeting efficiency of these lipid nanoparticles. DTP value for BPE-CH-NLCs (93.16%) was significantly (p < 0.05) higher than BPE-Sol (81.63%), indicating the efficient targeting potential of lipid nanoparticles compared to drug solutions Finally, it could be possible to infer that GMS-Oleic acid-based NLCs coated with CH might be effective carriers to administer BPE to the brain via the nasal route. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Related Products of 31566-31-1).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Related Products of 31566-31-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics