Phytochemical, anti-inflammatory, antioxidant, cytotoxic and antibacterial study of Capparis cartilaginea decnefrom Yemen was written by Moharram, Bushra Abdulkarim;Al Mahbashi, Hassan M.;SaifAli, Riyadh;Aqlan, Faten Ali. And the article was included in International Journal of Pharmacy and Pharmaceutical Sciences in 2018.Category: esters-buliding-blocks The following contents are mentioned in the article:
Objective: To investigate phytochems. and biol. activities of Capparis cartilaginea extracts Methods: The methanolic extracts of leaves, stem and twigs of C. cartilaginea were screened for their phytochems. The essential oil of the leaves was hydrodistd. by a Clevenger apparatus and analyzed by gas chromatog.-mass spectrometry (GC-MS). The leaves extract of C. cartilaginea was evaluated for its anti-inflammatory effect, using formalin-induced paw edema. The leaves, stem and twig extracts were assessed for their antioxidant activity, using free radical scavenging assay, cytotoxic activity, using 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay and antibacterial activity, using the microdilution method. Results: All extracts of C. cartilaginea contained alkaloids, carbohydrates, protein, coumarin, phytosterols, bitter principles, phenols and tannins. The essential oil of the leaves was mainly composed of iso-Pr isothiocyanate (69.4%), butane,1-isothiocyanate (26.97%) and iso-Bu isothiocyanate (3.26%). The leaves extract at doses of 200 and 400 mg/kg, significantly inhibited paw edema at the 3rd h (49.1%, 54.0%, resp.) and this effect was comparable to that of diclofenac (58.87%). The leaves extract showed the highest antioxidant activity with IC50 value of 91.71渭g/mL. The twigs extract exhibited the highest cytotoxic activity against human lung carcinoma (A549) with IC50 of 57.5渭g/mL. The leaves and stem extracts exhibited antibacterial activity against Staphylococcus aureus with min. inhibitory concentration (MIC) of 5.0 mg/mL. Conclusion: The leaves extract of C. cartilaginea is a potential source of bioactive compounds that could have a role in anti-inflammation. Twigs extract of the C. cartilaginea possesses a potential cytotoxic effect on human lung cell line. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Category: esters-buliding-blocks).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 纬-valerolactone.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics