Topical delivery of clobetasol propionate loaded nanosponge hydrogel for effective treatment of psoriasis: Formulation, physicochemical characterization, antipsoriatic potential and biochemical estimation was written by Kumar, Sunil;Prasad, Minakshi;Rao, Rekha. And the article was included in Materials Science & Engineering in 2021.Quality Control of Diphenyl carbonate The following contents are mentioned in the article:
Clobetasol propionate (CP), a superpotent topical corticosteroid, holds great promise for psoriasis treatment. However, common side effects like skin atrophy, steroidal acne, hypopigmentation and allergic contact dermatitis associated with it, hamper its utility for topical application. Taking this into consideration, the current work was aimed to fabricate CP loaded cyclodextrin nanosponge (CDNS) based hydrogel, to alleviate the aforementioned side effects, while controlling drug release. Nanosponges were crafted employing 尾-cyclodextrin (polymer) and di-Ph carbonate (cross linker) and evaluated appropriately. The selected formulation augmented 45 folds water solubility, with respect to pure CP. The formulation possessed entrapment efficiency (56.33 卤 0.94%), particle size (194.27 卤 49.24 nm) with polydispersitive index (0.498 卤 0.095), surface charge (-21.83 卤 0.95 mV) and drug release (86.25 卤 0.28%). Selected CP-CDNS were found crystalline and uniform in size. Further, in vitro cell viability anal. has been performed using THP1 cells to evaluate cytocompatibility of CP nanosponges. The chosen CP nanosponges were then embedded into Carbopol hydrogel, and characterized for rheol. behavior, spreadability, and texture profile. The developed nanoformulations were also assessed in vivo using mouse tail model. Histol. and biochem. assessments have been conducted to explore their antipsoriatic activity via oxidative stress biomarkers. The degree of orthokeratosis was observed remarkably (p < 0.001) amplified by CP-CDNS14 hydrogel as compared to untreated group (control) and CP hydrogel. In addition, drug activity and change in epidermal thickness were found significant. Our findings altogether advocated the profound potential of prepared CP nanogel in the topical treatment of psoriasis, with improved patient compliance. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0Quality Control of Diphenyl carbonate).
Diphenyl carbonate (cas: 102-09-0) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Quality Control of Diphenyl carbonate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics