Formulation and evaluation of 尾 -cyclodextrin microbeads as a carrier for DPI was written by Keshri, Priyanka;Khare, Ekta;Gupta, Abhay;Bhargava, Gaurav. And the article was included in International Journal of Pharmacy and Pharmaceutical Research in 2021.Computed Properties of C13H10O3 The following contents are mentioned in the article:
Conventional forms of DPI鈥瞫 are prepared by micronization methods which are often blends of fine drug particles and lactose as a carrier where drug particles are expected to adhere to the carrier surface. This leads to only 30% of drug deposition in the lung region from the conventional form of DPI. The micronization process mainly affects the mean median aerodynamic diameter (MMAD) and fine particle fraction (FPF) of the DPI resulting in less lung deposition. This leads to an increased frequency of administration. To optimize the delivered dose, conventional formulations can be substituted by engineered powders containing the active ingredient (API) alone or in combination with excipients displaying various properties such as liposomes, poly (lactic-co-glycolic acid) (PLGA), or leucine. Several strategies have already been developed including promising nanoparticles, while some safety concerns still need to be addressed. Increased lung persistence is of particular interest in various pulmonary pathologies. Among them, asthma is characterized by chronic airway inflammation. Innate and adaptive immunity effectors induce mucus overproduction, bronchial hyper-reactivity, and airway wall re-modeling leading to variable levels of airflow obstruction. Inhaled corticosteroids such as budesonide are used as first-line therapy agents to reach control airway inflammation and therefore to improve patient pulmonary functions. Several major parameters influence the activity of corticosteroids including the lung residence time which is highly influenced by the release rate locally obtained. Indeed, a decrease in absorption out of the lungs will extend the contact time between corticosteroids and their receptors, thus enhancing their anti-inflammatory effect. By considering all these limitations, there is a need for carrier-free budesonide loaded microbeads DPI formulation with sustained drug release which could be useful to enhance the deposition of drugs in the lungs. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0Computed Properties of C13H10O3).
Diphenyl carbonate (cas: 102-09-0) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Computed Properties of C13H10O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics