Mechanistic evaluation of lymphatic targeting efficiency of Atazanavir sulfate loaded lipid nanocarriers: In-vitro and in-vivo studies was written by Desai, Jagruti;Thakkar, Hetal. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Application of 31566-31-1 The following contents are mentioned in the article:
In the present study, Atazanavir sulfate-loaded solid lipid nanoparticles (ATZ-SLNs) were developed and characterized for oral bioavailability enhancement and lymphatic absorption. ATZ-SLNs were formulated by emulsion-solvent evaporation technique using hydrogenated castor oil and sodium oleate. The optimized formulation had a mean particle size of 190.1 卤 2.45 nm, the zeta potential of -42.63 卤 2.46 mV and entrapment efficiency of 94.26 卤 2.12%. Transmission electron microscopy and Field emission-SEM morphol. indicated discrete and round structures without aggregation. In-vitro drug release study showed controlled drug release of 80.36% in 12 h in simulated intestinal fluid. Cell-line study in Caco-2 cells showed increased permeability upon SLN formulation and mode of cellular uptake of SLN as clathrin and caveoli mediated endocytosis. In-vivo pharmacokinetic study in rats indicated increased oral bioavailability using ATZ-SLNs by 200% compared to suspension formulation. A lymphatic transport study revealed that SLNs were transported via lymphatic vessels. In organ biodistribution study, peyer’s patch region showed a 4.5 fold higher uptake of ATZ through ATZ-SLNs formulation than non-peyer’s patch region and high accumulation in spleen and brain. This delivery approach could maximize the drug concentrations to the lymphatic system leading to effective therapy for HIV. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Application of 31566-31-1).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 纬-valerolactone.Application of 31566-31-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics