Study of bioactivities of lipid content of fresh Lagenaria siceraria seeds pulp and identification of its chemical constituents was written by Chaudhery, Raza;Ahmed, Dildar;Liaqat, Inam;Dar, Parsa;Shaban, Muhammad. And the article was included in Journal of Medicinal Plants Research in 2014.Formula: C15H22O2 The following contents are mentioned in the article:
The aim of the present work was to analyze antimicrobial activities of the lipid content of seeds pulp of the fresh fruit of Lagenaria siceraria and identification of its chem. constituents by gas chromatog.-mass spectrometry (GC-MS). Methanolic extract of the seeds pulp exhibited moderate to good efficacy against Achromobacter xylosoxidans, Pseudomonas aeruginosa, Bacillus megaterium and Escherichia coli having zone of inhibition (ZOI) 21.5, 20.0, 17.5 and 15.0 mm, resp., at concentration 100 mg/mL. It showed better potency than antibiotic amoxylin against Enterobacter aerogenes, P. aeruginosa and Bacillus megaterium. The hexane fraction, that contained most of the lipid content, exhibited highest lethality against all the test microorganisms with ZOI 16.0 to 30.0 mm. It displayed highly significant efficacy against B. megaterium and Salmonella typhi with ZOI 30.0 and 22.5 mm, resp. Min. inhibitory concentration (MIC) of hexane fraction against B. megaterium and A. xylosoxidans was 0.40 mg/mL, while for others it ranged from 0.80 to 2.80 mg/mL. Palmitic acid exhibited significant potency against Staphylococcus aureus (ZOI, 20.0 mm, at concentration of 40 mg/mL), and moderately good efficacy against Stenotrophomonas maltophilia, Salmonella typhi and Enterobacter cloacae. Most compounds identified in the seeds pulp through GC-MS anal. were fatty acids or their esters. The compounds present in considerable concentration included azelaic acid (31.0%), (Z,Z)-9,12-octadecadienoic acid Me ester (27.75%), and palmitic acid Me ester (13.0%). Major component of Et acetate fraction was 4-hydroxybenzenemethanol (19.28%), while chloroform fraction contained 4-methoxymethylphenol (6.42%) and pentanoic acid 2-hydroxy-4-methyl-Me ester (6.75%) as major constituents. The lipid content of seeds pulp of Lagenaria siceraria fruit contains components which are capable to inhibit bacterial growth, and the ones with strong anti-oxidative potential. This study involved multiple reactions and reactants, such as 2-Ethylhexyl benzoate (cas: 5444-75-7Formula: C15H22O2).
2-Ethylhexyl benzoate (cas: 5444-75-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Formula: C15H22O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics