A review on non aqueous nano emulsion was written by Adinath, Bade Gautam;Anil, Ingale Divya. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2022.Recommanded Product: Glyceryl monostearate The following contents are mentioned in the article:
A review. Generally emulsions are water-in-oil or oil-inwater type, but emulsions may contain polar liquid as one of the phase. Non-aqueous nanoemulsions are useful in many situations where presence of water is not desirable, and formulation of active ingredients which undergo hydrolysis or oxidationin the presence of water. The non-aqueous nano emulsion subject to design a stable non-aqueous nanoemulsion (NANE) using cosmetically approved ingredients as a vehicle for the water-sensitive active ingredients. Non-aqueous nanoemulsion subject to increase the dermal penetration and permeation and study solubility and dermal bioavailability of drug. For better compliance, the nonaqueous nano emulsions will be incorporated in cosmetics or personal care products. A nonaqueous system was obtained with glycerin and olive oil stabilized by glycerol monosterate with co-surfactant. It was observed that emulsification behavior is completely unpredictable and conventional theories of emulsification and HLB system cannot be applied here. An optimized nonaqueous nano-emulsion is obtained through implementation of pseudoternary phase curve. Nonaqueous nano-emulsion region is determined and further characterized for pH, rheol., globule size anal., zeta potential and stability. Stability studies (agitation, centrifugation, freeze thaw cycle, accelerated stability) were carried out at 5, 25 and 40 degree C. Result proved that nonaqueous nano-emulsion can be used as vehicle for the poorly watersol. drug, suspension vehicles and oleogels. Non-aqueous nano-emulsion dosage forms have nano-sized droplets of disperse phase and are kinetically stable dosage form. Non-aqueous nanoemulsions are included under the category of new drug delivery system containing emulsified water in oil/oil in water system having mean globule size ranges from 10 nm to 1000 nm. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Recommanded Product: Glyceryl monostearate).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: Glyceryl monostearate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics