《Copper(II)-Photocatalyzed N-H Alkylation with Alkanes》 was published in ACS Catalysis in 2020. These research results belong to Zheng, Yi-Wen; Narobe, Rok; Donabauer, Karsten; Yakubov, Shahboz; Koenig, Burkhard. Product Details of 4248-19-5 The article mentions the following:
A practical method for the alkylation of N-H bonds of nitrogen nucleophiles/amides/sulfonamides with alkanes using a photoinduced copper(II)-peroxide catalytic system to afford alkylated nitrogen derivatives I [R1 = C(O)Ph, C(O)Me, indol-1-yl, etc.; R2 = n-pentyl, cyclopentyl, cyclohexyl, etc.] was reported. Upon light irradiation, the peroxide served as a hydrogen atom transfer reagent to activate stable C(sp3)-H bonds for the reaction with a broad range of nitrogen nucleophiles. The method enabled the chemoselective alkylation of amides and was utilized for the late-stage functionalization of NH-bond containing pharmaceuticals with good to excellent yields. The mechanism of the reaction was preliminarily investigated by radical trapping experiments and spectroscopic methods. The experimental process involved the reaction of tert-Butyl carbamate(cas: 4248-19-5Product Details of 4248-19-5)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Product Details of 4248-19-5
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