Name: Methyl 3-oxovalerateOn May 18, 2021 ,《Design, Synthesis, and Structure-Activity Relationship Study of Pyrazolones as Potent Inhibitors of Pancreatic Lipase》 appeared in ChemMedChem. The author of the article were Zhang, Jing; Yang, Yang; Qian, Xing-Kai; Song, Pei-Fang; Zhao, Yi-Shu; Guan, Xiao-Qing; Zou, Li-Wei; Bao, Xiaoze; Wang, Hong. The article conveys some information:
In this study, a series of pyrazolones was synthesized, and their inhibitory effects against pancreatic lipase (PL) were assayed by using 4-methylumbelliferyl oleate (4-MUO) as optical substrate for PL. Comprehensive structure-activity relationship anal. of these pyrazolones led us to design and synthesize a novel compound I as a potent mixed-competitive inhibitor of PL (IC50=0.30μM). In addition, compound I displayed some selectivity over other known serine hydrolases. A mol. docking study for compound I demonstrated that the inhibitory activity of compound I towards PL could be attributed to the π-π interactions of 2-naphthyl unit and hydrophobic interactions of Ph moiety with the active site of PL. Thus, compound I could serve as promising lead compound for the development of more efficacious and selective pyrazolones-type PL inhibitors for biomedical applications. In the experimental materials used by the author, we found Methyl 3-oxovalerate(cas: 30414-53-0Name: Methyl 3-oxovalerate)
Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Name: Methyl 3-oxovalerate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics