Yang, Lian; Zhang, Cheng-Pan published their research in ACS Omega in 2021. The article was titled ãRevisiting the Balz-Schiemann Reaction of Aryldiazonium Tetrafluoroborate in Different Solvents under Catalyst- and Additive-Free Conditionsã?Reference of Methyl 4-fluorobenzoate The article contains the following contents:
The thermal and photochem. Balz-Schiemann reaction in commonly used solvents was revisited under catalyst- and additive-free conditions. The study showed that using low- or non-polar solvents could improve the pyrolysis and photolysis of aryldiazonium tetrafluoroborates, enabling effective fluorination at a low temperature or under visible-light irradiation PhCl and hexane were exemplified as cheap and reliable solvents for both reactions, providing good to excellent yields of aryl fluorides ArF [Ar = Ph, 4-FC6H4, 3,4,5-tri-MeOC6H2, etc.] from the corresponding diazonium tetrafluoroborates. The combination of slight heating with visible-light irradiation was beneficial for the transformation of stable aryldiazonium tetrafluoroborates. Nevertheless, the electronic and steric nature of aryldiazonium tetrafluoroborates still had a pivotal effect on both fluorinations even in these solvents. In the experimental materials used by the author, we found Methyl 4-fluorobenzoate(cas: 403-33-8Reference of Methyl 4-fluorobenzoate)
Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Reference of Methyl 4-fluorobenzoate
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