《Copper-catalyzed sp3-carbon radical/carbamoyl radical cross coupling: A direct strategy for carbamoylation of 1,3-dicarbonyl compounds》 was published in Tetrahedron in 2020. These research results belong to Yan, Xu-Ping; Li, Cheng-Kun; Zhou, Shao-Fang; Shoberu, Adedamola; Zou, Jian-Ping. Product Details of 4949-44-4 The article mentions the following:
A novel copper-catalyzed sp3-carbon radical/carbamoyl radical cross-coupling protocol for the construction of C(sp3)-C(O) bond was described. This provided a straightforward method for synthesis of 2-carbamoyl-1,3-dicarbonyl compounds R1C(O)CH(C(O)R)C(O)R2 [R = NMe2, NEt2, N(i-Pr)2, N(n-Bu)2, morpholino; R1 = Me, Ph, 2-MeC6H4, etc.; R2 = Me, OEt, Ph, etc.] in good to excellent yields under mild conditions. Mechanistic studies confirmed the generation of both carbamoyl and C(sp3)-centered radicals directly from oxidation of C(sp3)-H bond of formamides and 1,3-dicarbonyl compounds, resp. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-oxopentanoate(cas: 4949-44-4Product Details of 4949-44-4)
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Product Details of 4949-44-4
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