In 2019,Synlett included an article by Yamamoto, Kosuke; Ishimaru, Keiko; Mizuta, Satoshi; Minato, Daishirou; Kuriyama, Masami; Onomura, Osamu. Reference of Diethyl 2-methylmalonate. The article was titled 《Diastereodivergent Synthesis of Bromoiminolactones: Electrochemical and Chemical Bromoiminolactonization of α-Allylmalonamides》. The information in the text is summarized as follows:
A diastereodivergent synthesis of N-substituted iminolactones I, II (R1 = Me, Et, Ph, etc.; R2 = Ph, cyclohexyl, benzyl, etc.) by bromoiminolactonization of α-substituted α-allylmalonamides R1C(CH2CH=CH2)(C(O)NHR2)2 is reported. Whereas bromocyclization under conventional chem. conditions provided cis-bromoiminolactones I, and electrochem. conditions exhibited complementary diastereoselectivity to afford the trans-products II. A variety of substituents on the nitrogen atoms and an α-position of the malonamide were tolerated under both sets of conditions to afford the corresponding iminolactones I, II in excellent yields and high diastereoselectivities. In the experiment, the researchers used Diethyl 2-methylmalonate(cas: 609-08-5Reference of Diethyl 2-methylmalonate)
Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Reference of Diethyl 2-methylmalonate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics