ãPET probe with Aggregation Induced Emission characteristics for the specific turn-on of aromataseã?was written by Wu, Renbo; Liu, Song; Liu, Yajing; Sun, Yuli; Xiao, Hao; Huang, Yong; Yang, Zequn; Wu, Zehui. Application of 51857-17-1 And the article was included in Talanta in 2020. The article conveys some information:
Aromatase is an attractive target for the diagnosis and treatment of breast cancer. To combine the anti-photobleaching properties of Aggregation Induced Emission (AIE) with the high sensitivity and whole-body imaging characteristics of positron emission tomog. (PET), the authors designed a bifunctional complexing agent with AIE characteristics by modifying the structure of tetraphenylethene, which is linked with triazole derivatives capable of complexing with naTGA3+/68Ga3+ to obtain [natGa/68Ga] 2 for targeting the aromatase. [natGa] 2 has typical AIE characteristics, which can form uniform nanomicelles above the critical micelle concentration, and illuminate estrogen receptor (+) MCF-7 cells. [natGa] 2 itself is almost nonemissive in PBS buffer solution, but it turns on its fluorescence upon interaction with human aromatase, with a detection limit of 0.15μg/mL [68Ga] 2 is easy to prepare and has high stability. Compared to the estrogen receptor that is neg. expressed by MDA-MB-231 cells, MCF-7 cells pos. expressing estrogen have a higher uptake of [naTGA] 2. The distribution of aromatase in a tumor can be co-localized by using [68Ga] 2. These results can be used to effectively assess estrogen receptor status and aromatase levels at the cellular level. The authors anticipate that this research could provide a new strategy for the fabrication of PET probes with AIE characteristics, providing useful probes for PET- FL (Fluorescence imaging) bimodal imaging. In the experiment, the researchers used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Application of 51857-17-1)
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsApplication of 51857-17-1
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