ãA new class of chiral pincer-type PNN ligands for Pd-catalyzed asymmetric allylic alkylationã?was published in Youji Huaxue in 2020. These research results belong to Wu, Dunqi; Cheng, Xuan; Liu, Yankai; Cheng, Guo; Guan, Xiaoyu; Deng, Qinghai. Synthetic Route of C8H14O4 The article mentions the following:
A new class of chiral tridentate P,N,N-donor pincer ligands bearing two or three stereocenters, 1-(4,5-dihydrooxazol-2-yl)-N-(2-(diphenylphosphanyl)benzyl) methanamines (oxpma) I (R1 = i-Pr, t-Bu; R2 = Me, i-Pr, Ph, Bn; R3 = H, Me; R4 = H, i-Pr, Ph), were synthesized starting from readily available amino acids R1CH(NH2)COOH in five or six steps. They were applied in palladium-catalyzed asym. allylic alkylation of allylic acetates ArCH(OAc)CH=CHAr (Ar = Ph, 3-chlorophenyl, 2-naphthyl, etc.) to afford the desired products (R/S,E)-ArCH(R5)CH=CHAr (R5 = CH2COOMe, CH2CC(O)Me, CH2CN, etc.) with high enantioselectivities (up to 96% ee). The results came from multiple reactions, including the reaction of Diethyl 2-methylmalonate(cas: 609-08-5Synthetic Route of C8H14O4)
Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Synthetic Route of C8H14O4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics