《Ring-Strain-Enabled Catalytic Asymmetric Umpolung C-O Bond-Forming Reactions of 1,2-Oxazetidines for the Synthesis of Functionalized Chiral Ethers》 was published in Organic Letters in 2020. These research results belong to Wu, Binyu; Yang, Jinggang; Gao, Min; Hu, Lin. Reference of N-tert-Butoxycarbonylhydroxylamine The article mentions the following:
An unprecedented catalytic asym. umpolung C-O bond-forming reaction of N-nosyl 1,2-oxazetidines with β-keto esters has been achieved in the presence of a chiral phase-transfer catalyst, allowing access to a range of highly functionalized chiral ethers bearing quaternary and no adjacent stereogenic centers with high yields, excellent enantioselectivities, and diastereoselectivities (up to 97% ee and 20:1 dr). These versatile products could be flexibly transformed into biol. important chiral fused and spiro morpholines in two steps.N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Reference of N-tert-Butoxycarbonylhydroxylamine) was used in this study.
N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Reference of N-tert-Butoxycarbonylhydroxylamine
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